B4750

N_α-Benzoyl-DL-arginin-2-naphthylamid -hydrochlorid

trypsin substrate

• Synonym(e): N_α-Benzoyl-DL-Arginin β-Naphthylamid -hydrochlorid, BANA
• Empirische Formel (Hill-System): C₂₃H₂₅N₅O₂ · HCl
• CAS-Nummer: 913-04-2
• Molekulargewicht: 439.94
• Beilstein: 3823291
• EG-Nummer: 213-015-4
• MDL-Nummer: MFCD00038940
• UNSPSC-Code: 12352204
• PubChem Substanz-ID: 24891699
• NACRES: NA.32

Eigenschaften

• Assay: ≥98% (TLC)
• Form: powder
• Löslichkeit: DMF: 50 mg/mL, clear, colorless to faintly yellow
• Lagertemp.: 2-8°C
• SMILES String: Cl[H].NC(=N)NCCCC(NC(=O)c1ccccc1)C(=O)Nc2ccc3ccccc3c2
• InChI: 1S/C23H25N5O2.ClH/c24-23(25)26-14-6-11-20(28-21(29)17-8-2-1-3-9-17)22(30)27-19-13-12-16-7-4-5-10-18(16)15-19;/h1-5,7-10,12-13,15,20H,6,11,14H2,(H,27,30)(H,28,29)(H4,24,25,26);1H
• InChIKey: BNGRKDJZQIGWQF-UHFFFAOYSA-N

Beschreibung

Anwendung

N_α-Benzoyl-DL-arginine β-naphthylamide hydrochloride has been used as a substrate in the BANA test to evaluate the inhibitory activity of stefin. It has also been used as a substrate for the determination of Ki values of inhibitors toward trypsin.

Biochem./physiol. Wirkung

N_α-Benzoyl-DL-arginine β-naphthylamide hydrochloride (BANA) helps to determine the activities of cathepsin B and papain. BANA test is also useful in identifying the number of periodontal sites with periodontal pathogens. Presence of volatile sulfur compounds (VSCs), synthesized by oral bacteria in dental plaque or tongue coating can be colorimetrically confirmed by their ability to hydrolyze N-benzoyl-DL-arginine-2-naphthylamide.

Substrate

A chromogenic substrate for trypsin.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)