B4397

Bradykinin Fragment 1-8 acetate salt hydrate

≥97% (HPLC)

• Synonym(e): [des-Arg⁹]-Bradykinin acetate salt hydrate
• Empirische Formel (Hill-System): C₄₄H₆₁N₁₁O₁₀ · xC₂H₄O₂ · yH₂O
• Molekulargewicht: 904.02 (anhydrous free base basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 24891773
• MDL number: MFCD00236892
• Assay: ≥97% (HPLC)
• Form: powder

Eigenschaften

• assay: ≥97% (HPLC)
• form: powder
• UniProt accession no.: P01042
• storage temp.: −20°C
• SMILES string: NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(=O)NC(CO)C(=O)N4CCCC4C(=O)NC(Cc5ccccc5)C(O)=O
• InChI: 1S/C44H61N11O10/c45-29(15-7-19-48-44(46)47)40(61)55-22-10-18-35(55)42(63)54-21-8-16-33(54)38(59)49-25-36(57)50-30(23-27-11-3-1-4-12-27)37(58)52-32(26-56)41(62)53-20-9-17-34(53)39(60)51-31(43(64)65)24-28-13-5-2-6-14-28/h1-6,11-14,29-35,56H,7-10,15-26,45H2,(H,49,59)(H,50,57)(H,51,60)(H,52,58)(H,64,65)(H4,46,47,48)
• InChI key: VCEHWDBVPZFHAG-UHFFFAOYSA-N
• Gene Information: human ... KNG1 (includes EG:3827)

Beschreibung

General description

Bradykinin Fragment 1-8, also known as des-Arg9-bradykinin, is produced by the cleavage of bradykinin at 8-9 position by carboxypeptidase N.

Application

Bradykinin Fragment 1-8 acetate salt hydrate has been used as a Bradykinin 1 receptor (B1R) agonist to investigate the expression and the role of B1R, in mediating neuronal injury under the chemical neurotoxicity paradigm in PC12 cell lines. It has also been used as an analyte in nanostructure-initiator mass spectrometry and matrix-assisted laser desorption/ionization (MALDI).

Biochem/physiol Actions

Bradykinin Fragment 1-8 is a selective B1 bradykinin receptor agonist. It promotes the release of nitric oxide, prostacyclin, endothelium-derived hyperpolarizing factor in the endothelium. des-Arg9-bradykinin also promotes vasodilatation and increases blood flow in the peripheral circulation.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)