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07039

Sigma-Aldrich

(R)-(+)-α-Liponsäure

≥98.0% (HPLC)

Synonym(e):

(R)-(+)-1,2-Dithiolan-3-valeriansäure, (R)-6,8-Dithiooctansäure, (R)-6,8-Thioctsäure

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About This Item

Empirische Formel (Hill-System):
C8H14O2S2
CAS-Nummer:
1200-22-2
Molekulargewicht:
206.33
MDL-Nummer:
MFCD01631142
UNSPSC-Code:
12352202
PubChem Substanz-ID:
329748332
NACRES:
NA.32

Qualitätsniveau

200

Assay

≥98.0% (HPLC)

Optische Reinheit

enantiomeric excess: ≥98.0% (HPLC)

mp (Schmelzpunkt)

48-52 °C (lit.)

Lagertemp.

−20°C

SMILES String

OC(=O)CCCC[C@@H]1CCSS1

InChI

1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1

InChIKey

AGBQKNBQESQNJD-SSDOTTSWSA-N

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Biochem./physiol. Wirkung

(R)-(+)-α-Lipoic acid was shown to significantly increase pyruvate oxidation while abrogating fatty acid oxidation in rat hepatocytes. These effects make R-(+)-α-Lipoic acid a promising treatment option for the treatment of Type II diabetes. It is a biological antioxidant with prooxidant activities, its therapeutic potential is widely investigated, e.g. in the treatment for Alzheimer′s disease.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Hinweis zur Analyse

identity confirmed by LC-MS

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Thioctsäure, enthält Unreinheit B European Pharmacopoeia (EP) Reference Standard

Y0000545

Thioctsäure, enthält Unreinheit B

Standardisierter Baldriantrockenextrakt European Pharmacopoeia (EP) Reference Standard

Y0000583

Standardisierter Baldriantrockenextrakt

Parthenolid ≥98% (HPLC)

Sigma-Aldrich

P0667

Parthenolid

Jennie L Walgren et al.
Metabolism: clinical and experimental, 53(2), 165-173 (2004-02-10)
R-(+)-alpha-lipoic acid (R-LA) is the naturally occurring enantiomer of LA. It is a strong antioxidant and cofactor of key metabolic enzyme complexes catalyzing the decarboxylation of alpha-keto acids. Racemic LA (rac-LA) has shown promise in treating diabetic polyneuropathy, and some
Dove J Keith et al.
Pharmacological research, 66(3), 199-206 (2012-05-23)
Lipoic acid (LA) shows promise as a beneficial micronutrient toward improving elder health. Studies using old rats show that (R)-α-LA (R-LA) significantly increases low molecular weight antioxidants that otherwise decline with age. Despite this rationale for benefiting human health, little
Takashi Yamada et al.
Neurochemistry international, 59(7), 1003-1009 (2011-10-13)
Growing evidence suggests that α-lipoic acid (LA) has neuroprotective effects in various pathological conditions including brain ischemia and neurodegeneration. While anti-oxidative activity has been thought to play a central role in LA-mediated neuroprotection, the precise mechanism and the effect of
Annette Maczurek et al.
Advanced drug delivery reviews, 60(13-14), 1463-1470 (2008-07-29)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that destroys patient memory and cognition, communication ability with the social environment and the ability to carry out daily activities. Despite extensive research into the pathogenesis of AD, a neuroprotective treatment -
Kate Petersen Shay et al.
Biochimica et biophysica acta, 1790(10), 1149-1160 (2009-08-12)
Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food. It is well-defined as a therapy for preventing diabetic polyneuropathies, and scavenges free radicals, chelates metals, and restores intracellular glutathione levels which otherwise
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