D1000000

Dibenzosuberon

Name: Dibenzosuberon
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(e):

5-Dibenzosuberon, 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-on, Dibenzocycloheptadienon

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Über diesen Artikel

Empirische Formel (Hill-System):

C₁₅H₁₂O

CAS-Nummer:

1210-35-1

Molekulargewicht:

208.26

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329798658

MDL number:

MFCD00003587

Beilstein/REAXYS Number:

1454355

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Produktname

Dibenzosuberon, European Pharmacopoeia (EP) Reference Standard

InChI key

BMVWCPGVLSILMU-UHFFFAOYSA-N

SMILES string

O=C1c2ccccc2CCc3ccccc13

InChI

1S/C15H12O/c16-15-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)15/h1-8H,9-10H2

grade

pharmaceutical primary standard

API family

nortriptyline, amitriptyline

manufacturer/tradename

EDQM

refractive index

n20/D 1.6332 (lit.)

bp

148 °C/0.3 mmHg (lit.)

mp

32-34 °C (lit.)

density

1.156 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

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Dieser Artikel	BP858	8.03559	PHR2836
D1000000 Dibenzosuberone	BP858 Dibenzosuberone	Sigma-Aldrich 8.03559 Dibenzosuberone	Supelco PHR2836 Amitriptyline Related Compound A
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade -	grade certified reference material, pharmaceutical secondary standard
manufacturer/tradename EDQM	manufacturer/tradename BP	manufacturer/tradename -	manufacturer/tradename -
format neat	format neat	format -	format -
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical pharmaceutical small molecule	application(s) -	application(s) pharmaceutical small molecule
API family nortriptyline, amitriptyline	API family nortriptyline, amitriptyline	API family -	API family amitriptyline
refractive index n20/D 1.6332 (lit.)	refractive index n20/D 1.6332 (lit.)	refractive index -	refractive index -

General description

Dieses Produkt wird, wie von der entsprechenden Pharmakopöe spezifiziert und geliefert, angeboten. Alle Informationen zu diesem Produkt, einschließlich SDB und jegliche Produktinformationen, wurden unter der Autorität der entsprechenden Pharmakopöe entwickelt und ausgestellt.
Weitere Informationen und Unterstützung finden Sie auf der Webseite der entsprechenden Pharmakopöe.

Other Notes

Kann Verkaufsbeschränkungen unterliegen.

Packaging

Dieses Produkt wird, wie von der entsprechenden Pharmakopöe geliefert, angeboten. Die aktuellen Mengeneinheiten finden Sie im Referenzsubstanzen-Katalog der EDQM.

Application

Dibenzosuberone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Comparable product

Produkt-Nr.

Beschreibung

Preisangaben

1029013

Amitriptyline Related Compound A, United States Pharmacopeia (USP) Reference Standard

1029002

Amitriptyline hydrochloride, United States Pharmacopeia (USP) Reference Standard

1474005

Nortriptyline hydrochloride, United States Pharmacopeia (USP) Reference Standard

N1280000

Nortriptyline hydrochloride, European Pharmacopoeia (EP) Reference Standard

PHR1384

Amitriptyline hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

Y0000563

Amitriptyline hydrochloride, European Pharmacopoeia (EP) Reference Standard

Y0001296

Nortriptyline for system suitability, European Pharmacopoeia (EP) Reference Standard

1029024

Amitriptyline Related Compound B, United States Pharmacopeia (USP) Reference Standard

PHR1776

Amitriptyline Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

BP269

Nortriptyline hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP016

Amitriptyline hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP858

Dibenzosuberone, British Pharmacopoeia (BP) Reference Standard

PHR3216

Nortriptyline Hydrochloride, pharmaceutical secondary standard, certified reference material

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

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Analysenzertifikate (COA)

Lot/Batch Number

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The control of impurities in amitriptyline hydrochloride using a reversed-phase hybrid stationary phase.

S P Dixon et al.

Pharmeuropa scientific notes, 2005(1), 15-20 (2007-08-11)

An isocratic reversed-phase liquid chromatographic method is described using a hybrid column for the control of synthetic impurities potentially found in amitriptyline hydrochloride. The method has been validated and is capable of controlling impurities to 0.1 per cent.

Design, synthesis, and biological evaluation of novel disubstituted dibenzosuberones as highly potent and selective inhibitors of p38 mitogen activated protein kinase.

Solveigh C Koeberle et al.

Journal of medicinal chemistry, 55(12), 5868-5877 (2012-06-09)

Synthesis, biological testing, structure-activity relationships (SARs), and selectivity of novel disubstituted dibenzosuberone derivatives as p38 MAP kinase inhibitors are described. Hydrophilic moieties were introduced at the 7-, 8-, and 9-position of the 2-phenylamino-dibenzosuberones, improving physicochemical properties as well as potency.

Synthesis of novel, potentially biologically active dibenzosuberone derivatives.

Sonja Merkas et al.

Molecules (Basel, Switzerland), 10(12), 1429-1437 (2007-11-17)

Novel representatives of the important group of biologically active dibenzosuberone derivatives were prepared: 3,7-dibromo-5-(dimethylaminoethyl- oxyimino)-10,11-dihydro-5H-dibenzo[a,d]cyclohepta-1,4-diene (1), 3,7-dibromo-5-(3- dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (2) and 1,7- dibromo-5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo-[a,d]-cycloheptene (3). These compounds are potential tricyclic antidepressants (TCAs), which are still the most frequently prescribed antidepressants in many

Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity.

Stefan Fischer et al.

Journal of medicinal chemistry, 56(1), 241-253 (2012-12-29)

p38α mitogen-activated protein (MAP) kinase is a main target in drug research concerning inflammatory diseases. Nevertheless, no inhibitor of p38α MAP kinase has been introduced to the market. This might be attributed to the fact that there is no inhibitor

Simulation of the hepatic metabolism of stilbene and its tricyclic derivatives by Fenton and Ruff reagents: models for cytochrome P-450 activation of chemical carcinogens.

S Zbaida et al.

Biopharmaceutics & drug disposition, 11(1), 39-51 (1990-01-01)

Reactions of trans-stilbene, cis-stilbene, 5H-dibenzo [a,d] cyclo-heptene 5-one and 5H-dibenz [b,f] azepine (iminostilbene) with Fenton reagent [Fe (II)/H2O2] clearly simulate their hepatic metabolism. Expoxidation on the corresponding ethylenic linkage was found to be a common pathway of these compounds. Epoxides

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