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AB2255

Sigma-Aldrich

Anti-GABA B Receptor R2 Antibody

serum, from guinea pig

Synonym(e):

G protein-coupled receptor 51, G-protein coupled receptor 51, GABA-B receptor 2, gamma-aminobutyric acid (GABA) B receptor, 2, gamma-aminobutyric acid B receptor, 2, GABA-B-R2, GABA(B)R2

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

guinea pig

Qualitätsniveau

100

Antikörperform

serum

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Speziesreaktivität

rhesus macaque, rat

Speziesreaktivität (Voraussage durch Homologie)

canine (based on 100% sequence homology), bovine (based on 100% sequence homology), human (based on 100% sequence homology), horse (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), mouse (based on 100% sequence homology)

Methode(n)

immunohistochemistry: suitable
western blot: suitable

NCBI-Hinterlegungsnummer

NP_113990

UniProt-Hinterlegungsnummer

O88871

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... GABBR2(9568)

Allgemeine Beschreibung

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.

Spezifität

This antibody recognizes the C-terminus of rat GABA-B-R2.

Immunogen

Bovine thyroglobulin-conjugated linear peptide at the C-terminus of rat GABA-B-R2.

Anwendung

Anti-GABA B Receptor R2 Antibody is an antibody against GABA B Receptor R2 for use in IH & WB.

Qualität

Evaluated by Immunohistochemistry in Purkinje cells in rat mid-brain region.

Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected GABA-B-R2 in Purkinje cells in rat mid-brain region.

Zielbeschreibung

Although a band is observed around the calculated molecular weight of 105 kDa, Western Blotting is not a recommened application for this antibody because the band is weak in comparison to other non-specific bands present.

Verlinkung

Replaces: AB5394

Hinweis zur Analyse

Control
Purkinje cells in rat mid-brain region

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Liang Zhang et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 41(6), 1467-1476 (2015-10-27)
Cortical network hyper-excitability is a common phenotype in mouse models lacking the transcriptional regulator methyl-CPG-binding protein 2 (MeCP2). Here, we implicate enhanced GABAB receptor activity stemming from diminished cortical expression of the GABA transporter GAT-1 in the genesis of this
Yupeng Miao et al.
Nature communications, 12(1), 4518-4518 (2021-07-28)
Multiplexed optical imaging provides holistic visualization on a vast number of molecular targets, which has become increasingly essential for understanding complex biological processes and interactions. Vibrational microscopy has great potential owing to the sharp linewidth of vibrational spectra. In 2017
Chuanyin Hu et al.
Molecular medicine reports, 15(2), 975-980 (2016-12-31)
Chemotherapeutic drugs commonly induce peripheral neuropathic pain, which limit their clinic use. In the present study, the effect of fucoidan on the development of vincristine‑induced neuropathic pain was evaluated and the underlying mechanism was examined. A neuropathy model was established
Khaled Zemoura et al.
The Journal of biological chemistry, 291(41), 21682-21693 (2016-08-31)
GABAB receptors are heterodimeric G protein-coupled receptors, which control neuronal excitability by mediating prolonged inhibition. The magnitude of GABAB receptor-mediated inhibition essentially depends on the amount of receptors in the plasma membrane. However, the factors regulating cell surface expression of
Emilia Favuzzi et al.
Cell, 184(15), 4048-4063 (2021-07-08)
Microglia, the resident immune cells of the brain, have emerged as crucial regulators of synaptic refinement and brain wiring. However, whether the remodeling of distinct synapse types during development is mediated by specialized microglia is unknown. Here, we show that
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