8.55035
DFPE polystyrene
Novabiochem®
Synonym(e):
2-(3,5-Dimethoxy-4-formylphenoxy)ethyl polystyrene
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NACRES:
NA.22
UNSPSC Code:
13111023
Technischer Dienst
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Unterstützung erhaltenQuality Segment
product line
Novabiochem®
form
beads
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
aldehyde
storage temp.
2-8°C
General description
This resin is prepared under conditions optimized to minimize styrene formation during attachment of the linker to the functionalized ethylpolystyrene support. This high substitution, coupled with the lack of amide bonds and potentially acid-sensitive benzylic linkages, makes this support the preferred choice of SPOS of secondary sulfonamides and carboxamides. Applications of FMPE include aminofurazanopyrazines [1] and peptide agonists for human orphan receptor BRS-3 [2].
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins Literature references
Literature references
[1] B. Dörner & P. White in ′Peptides 1998, Proc. 25th European Peptide Symposium′, S. Bajusz & F. Hudecz (Eds), Budapest, Akadémiai Kiadó, 1999, pp. 90.
[2] M. Grimstrup & F. Zaragoza (2002) Eur. J. Org. Chem., 2953.
[3] K. J. Jensen, et al. (1998) J. Am. Chem. Soc., 120, 5441.
[4] M. del Fresno, et al. (1998) Tetrahedron Lett., 39, 2639.
[5] N. S. Gray, et al. (1997) Tetrahedron Lett., 38, 1161.
[6] J. Alsina, et al. (1999) Chem. Eur. J., 5, 2787.
[7] J. F. Tolborg & K. J. Jensen (2000) Chem. Commun., 147.
[8] A. E. Fenwick, et al. (2001) Bioorg. Med. Chem. Lett., 11, 195.
[9] J. Giovannoni, et al. (2001) Tetrahedron Lett., 42, 5389.
[10] J. T. Bork, et al. (2003) Org. Lett., 5, 117.
[11] C. P. Holmes, Paper ORGN 383 presented at the 213th National Meeting of the American Chemical Society, San Francisco, 1997.
[12] C. Pégurier, et al. (2000) Bioorg. Med. Chem., 8,163.
[13] T. F. Herpin, et al. (2000) J. Comb. Chem., 2, 513.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins Literature references
Literature references
[1] B. Dörner & P. White in ′Peptides 1998, Proc. 25th European Peptide Symposium′, S. Bajusz & F. Hudecz (Eds), Budapest, Akadémiai Kiadó, 1999, pp. 90.
[2] M. Grimstrup & F. Zaragoza (2002) Eur. J. Org. Chem., 2953.
[3] K. J. Jensen, et al. (1998) J. Am. Chem. Soc., 120, 5441.
[4] M. del Fresno, et al. (1998) Tetrahedron Lett., 39, 2639.
[5] N. S. Gray, et al. (1997) Tetrahedron Lett., 38, 1161.
[6] J. Alsina, et al. (1999) Chem. Eur. J., 5, 2787.
[7] J. F. Tolborg & K. J. Jensen (2000) Chem. Commun., 147.
[8] A. E. Fenwick, et al. (2001) Bioorg. Med. Chem. Lett., 11, 195.
[9] J. Giovannoni, et al. (2001) Tetrahedron Lett., 42, 5389.
[10] J. T. Bork, et al. (2003) Org. Lett., 5, 117.
[11] C. P. Holmes, Paper ORGN 383 presented at the 213th National Meeting of the American Chemical Society, San Francisco, 1997.
[12] C. Pégurier, et al. (2000) Bioorg. Med. Chem., 8,163.
[13] T. F. Herpin, et al. (2000) J. Comb. Chem., 2, 513.
Analysis Note
Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined by elemental analysis of sulfur after derivatization with tosylhydrazide): 0.50 - 1.10 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene-1 % DVB), 100 -200 mesh
Appearance of substance (visual): beads
Loading (determined by elemental analysis of sulfur after derivatization with tosylhydrazide): 0.50 - 1.10 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene-1 % DVB), 100 -200 mesh
Other Notes
Replaces: 01-64-0360
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Lagerklasse
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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