8.55012
Trityl chloride resin
Novabiochem®
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UNSPSC Code:
12352101
product line
Novabiochem®
form
beads
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
storage temp.
2-30°C
General description
An acid-labile resin for the solid phase immobilization of alcohols [1,2,3,4,5], amines [4, 6,7,8,9,10,11,12], sugars [13], O- and N-linked hydroxylamines [14,15], imidazoles [16] and carboxylic acids [16]. Release of these functionalities is generally achieved using 1-5% TFA in DCM containing 5% TIS. Amines can also be cleaved with 30% HFIP in DCM [4]. This resin, although very acid sensitive, can also be used in peptide synthesis [17].
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] C. C. Leznoff (1978) Acc. Chem. Res., 11, 327.
[2] C. Chen, et al. (1994) J. Am. Chem. Soc., 116, 2661.
[3] Z. Li & A. Ganesan (1998) Syn. Lett., 405.
[4] P. Athanassopoulos, et al., Poster 316 presented at the 24thEuropean Peptide Symposium, Edinburgh, 1996.
[5] K. Barlos, et al. (1988) Liebigs Ann. Chem., 1079.
[6] K. Barlos, et al. in ′Peptides 1992, Proc. 22nd European Peptide Symposium′, C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden,1993, pp. 281.
[7] M. Schuster, et al. (1996) Angew. Chem. Int. Ed. Engl., 35, 1979.
[8] P. Garibay, et al. (1998) Tetrahedron Lett., 39, 2207.
[9] Y. Guan, et al. (2000) J. Comb. Chem., 2, 297.
[10] S. Manku, et al. (2001) J. Org. Chem., 66, 874.
[11] D. Jönsson, et al. (2001) Tetrahedron Lett., 42, 6953.
[12] C. A. Olsen, et al. (2003) Org. Lett., 5, 4183.
[13] F. Peri, et al. (2000) Tetrahedron Lett., 41, 8587.
[14] U. Bauer, et al. (1997) Tetrahedron Lett., 38, 7233.
[15] O. Kinzel, et al. (2003) J. Peptide Sci., 9, 375.
[16] D. P. Matthews, et al. (2000) J Comb. Chem., 2,19.
[17] K. Barlos, et al. (1989) Tetrahedron Lett., 30, 3943.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] C. C. Leznoff (1978) Acc. Chem. Res., 11, 327.
[2] C. Chen, et al. (1994) J. Am. Chem. Soc., 116, 2661.
[3] Z. Li & A. Ganesan (1998) Syn. Lett., 405.
[4] P. Athanassopoulos, et al., Poster 316 presented at the 24thEuropean Peptide Symposium, Edinburgh, 1996.
[5] K. Barlos, et al. (1988) Liebigs Ann. Chem., 1079.
[6] K. Barlos, et al. in ′Peptides 1992, Proc. 22nd European Peptide Symposium′, C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden,1993, pp. 281.
[7] M. Schuster, et al. (1996) Angew. Chem. Int. Ed. Engl., 35, 1979.
[8] P. Garibay, et al. (1998) Tetrahedron Lett., 39, 2207.
[9] Y. Guan, et al. (2000) J. Comb. Chem., 2, 297.
[10] S. Manku, et al. (2001) J. Org. Chem., 66, 874.
[11] D. Jönsson, et al. (2001) Tetrahedron Lett., 42, 6953.
[12] C. A. Olsen, et al. (2003) Org. Lett., 5, 4183.
[13] F. Peri, et al. (2000) Tetrahedron Lett., 41, 8587.
[14] U. Bauer, et al. (1997) Tetrahedron Lett., 38, 7233.
[15] O. Kinzel, et al. (2003) J. Peptide Sci., 9, 375.
[16] D. P. Matthews, et al. (2000) J Comb. Chem., 2,19.
[17] K. Barlos, et al. (1989) Tetrahedron Lett., 30, 3943.
Analysis Note
Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Ala-Leu loaded resin): 1.1 - 1.7 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
The polymer matrix is copoly (styrene-1 % DVB), 200 - 400 mesh
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Ala-Leu loaded resin): 1.1 - 1.7 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
The polymer matrix is copoly (styrene-1 % DVB), 200 - 400 mesh
Other Notes
Replaces: 01-64-0074
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Lagerklasse
11 - Combustible Solids
wgk
WGK 1
flash_point_c
Not applicable
flash_point_f
Not applicable
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