SML1779
Nigericin sodium salt
from Streptomyces hygroscopicus, ≥98% (HPLC), solution, polyether ionophore
Synonym(s):
3B2-6379, Antibiotic K178, Antibiotic X464, Azalomycin M, HE331800, Helexin C, Polyetherin A, sodium;2-[(3S,6R)-6-[[(5R,6R,7R,9R)-2-[5-[(3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoate
About This Item
Recommended Products
product name
Nigericin sodium salt Ready Made Solution, 5 mg/mL (DMSO:ethanol 1:1)
biological source
Streptomyces hygroscopicus
Quality Level
form
solution
concentration
5 mg/mL (DMSO:ethanol 1:1)
antibiotic activity spectrum
Gram-positive bacteria
Mode of action
cell membrane | interferes
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25?,26?,27+,28+,29+,30+,31+,32?,33?,34-,35?,37?,38?,39-,40+;/m0./s1
InChI key
MOYOTUKECQMGHE-KKCUGXASSA-M
Related Categories
Biochem/physiol Actions
Nigericin kills bacteria by facilitating the diffusion of ions across membranes.
Low concentration (0.5 μM) of Nigericin rapidly decreases pHi, causing stimulation of PG production 1.5- to 2-fold in cerebral microvascular endothelial cells and arresting of DNA synthesis in Erlich acites carcinoma cells. Treatment of Hela cells, after entry of poliovirus, with nigericin, prevents the inhibition of host protein synthesis by poliovirus. Nigericin is also widely used in studies of the consequences of changes in membrane potential in variable systems.
Preparation Note
Storage and Stability
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Flam. Liq. 3
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point(F)
78.8 °F
Flash Point(C)
26 °C
Certificates of Analysis (COA)
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