G1/S-specific cyclin-E1 (Cyclin E) is a regulatory subunit of CDK2 during G1 phase and controls G1/S transition during the mammalian cell cycle. The Cyclin E/CDK2 complex phosphorylates p27Kip1 and truncated variant isoforms of cyclin E can phosphorylate histone H1 to initiate DNA synthesis. Multiple isoforms of cyclin E are identified in tumor tissues.
Immunogen
Near the C-terminus of the human cyclin E1 protein.
Features and Benefits
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Physical form
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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