The telomeric repeat binding factor 2 (TRF2 ) gene codes for a component of shelterin. The encoded protein is dimer containing four domains : B domain at the N-terminal, the TRF homology domain, the hinge domain and the MYB/SANT (proto-oncogene, transcription factor telobox) domain at C-terminal.
Immunogen
The epitope recognized by PLA0144 maps to a region between residue 375 and 425 of human Telomeric Repeat Binding Factor 2 using the numbering given in entry NP_005643.1 (GeneID 7014).
Biochem/physiol Actions
TRF2 (telomeric repeat binding factor 2) is responsible for telomere stability by the insertion of the 3′ overhang. TRF2 offers protection to DNA from being wrongly recognized by the DNA damage repair systems. Loss of TRF2 function induces DNA repair system resulting in apoptosis by causing cell cycle arrest. Upregulation of the TRF2 gene is observed in cancer and thus concluded to contribute to tumor progression.
Telomeric repeat binding factor (TRF2) is a ubiquitously expressed protein that localizes at chromosome ends during all phases of the cell cycle and binds directly to TTAGGG repeats. TRF2 functions to protect telomeres as being perceived as sites of DNA damage. TRF2 interacts with several proteins at telomeres, such as Rap1, Mre11, Rad50, and NBS1.
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12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Telomeric repeat-binding factor 2: a marker for survival and anti-EGFR efficacy in oral carcinoma.
Benhamou Y, et al.
Oncotarget, 7(28), 44236-44236 (2016)
Expression of Telomere Repeat Binding Factor 1 and TRF2 in Prostate Cancer and Correlation with Clinical Parameters.
Chen W, et al.
BioMed Research International, 2017, 9764752-9764752 (2017)
ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2.
Picco V, et al.
Oncotarget, 7(29), 46615-46615 (2016)
HULC cooperates with MALAT1 to aggravate liver cancer stem cells growth through telomere repeat-binding factor 2.
Wu M, et al.
Scientific Reports, 6, 36045-36045 (2016)
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