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P2172

Sigma-Aldrich

C-Phycocyanin from Spirulina sp.

lyophilized powder

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About This Item

CAS Number:
11016-15-2
MDL number:
MFCD00130691
UNSPSC Code:
12352202
NACRES:
NA.56

biological source

Spirulina

Quality Level

200

form

lyophilized powder

composition

Protein, ~40% Lowry

concentration

30-50% protein (Lowry)

storage temp.

2-8°C

Gene Information

Spirulina ... cpcA(41380954) , cpcB(41380955)

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General description

C-Phycocyanin is a protein pigment, that is soluble in water. It is an important constituent of Spirulina platensis.

Application

C-Phycocyanin from Spirulina sp. has been used:
  • as a standard to characterize the fluorescence interactions and oxidation behaviors for model compounds
  • as a standard to confirm the antibacterial activity
  • to characterize the recombinantly expressed α-subunit of C-phycocyanin from Synechocystis sp. PCC6803 (HisCPC)
  • to identify the phycocyanin from water extracted Spirulina maxima sample

Biochem/physiol Actions

C-phycocyanin, a biliprotein with antioxidant properties, was shown to induce apoptosis in HeLa cells by stimulating expression of pro-apoptotic genes as well as by inducing increased release of cytochrome c from the mitochondria.
C-phycocyanin can act as an active inhibitor of A53Tα-synuclein. It possess anti-inflammatory properties.

Packaging

Package size based on protein content

Physical form

Partially purified, contains sucrose, dithioerythritol and sodium azide as preservatives

Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Statements

H302 + H332,H311,H411

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Screening of anti-bacterial activity of C-phycocyanin and its minimum inhibitory concentration (MIC) determination by agar dilution method
Murugan T and Madhavan R
Asian Journal of Biological Sciences, 6(1), 41-45 (2011)
Evaluating fluorescence spectroscopy as a tool to characterize cyanobacteria intracellular organic matter upon simulated release and oxidation in natural water
Korak JA, et al.
Water Research, 68(1), 432-443 (2015)
Protective effect of water extracted Spirulina maxima on glutamate-induced neuronal cell death in mouse hippocampal HT22 cell
Lee HY, et al.
Pharmacognosy magazine, 14(54), 242-242 (2018)
Bing Li et al.
Biotechnology and applied biochemistry, 43(Pt 3), 155-164 (2005-12-01)
C-phycocyanin (C-PC), a water-soluble protein pigment, isolated from Spirulina platensis, is of great importance because of its various medical and pharmacological properties. In the present study, we first investigated the effect of highly purified C-PC on growth and proliferation of
C-Phycocyanin from Spirulina Inhibits ?-Synuclein and Amyloid ?-Fibril Formation but Not Amorphous Aggregation
Liu Y, et al.
Journal of Natural Products, 82(1), 66-73 (2019)
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