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F5386

Sigma-Aldrich

Fibrin from human plasma

insoluble powder

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About This Item

CAS Number:
EC Number:
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.61

biological source

human plasma

Quality Level

form

powder

technique(s)

indirect ELISA: suitable

UniProt accession no.

InChI

1S/C5H11N3O2/c1-7-5(10)3-8-4(9)2-6/h2-3,6H2,1H3,(H,7,10)(H,8,9)

InChI key

BWGVNKXGVNDBDI-UHFFFAOYSA-N

Gene Information

General description

Fibrin is produced from cross-linking of fibrinogen by thrombin. Fibrinogen is made up of two monomers each containing three polypeptide chains. Fibrinogen is a major plasma protein.

Application

Fibrin from human plasma has been used:
  • for in vitro cleavage of fibrinogen and fibrin
  • as a reference for true component analysis (TCA) and principal component analysis (PCA) of Raman spectra
  • as a reference in Raman spectroscopy to study the binding mechanisms and the binding efficiency of the different polyoxometalates (POMs)

Biochem/physiol Actions

Fibrin acts as an important bio-polymer in the primary blood clotting process. It creates a scaffold for infiltrating cells during tissue repair. Fibrin is widely used as a tissue sealant for tissue regeneration applications as it enables the formation of a biocompatible physical structure. It is also used in delivery systems for cells and bioactive molecules. The fibrin matrix resembles the native pancreas and can serve as a scaffold material for islet transplantation. Fibrin has been used in studies to obtain fibrin-specific monoclonal antibodies (mAbs). These mAbs may be used to determine their role in fibrin polymerization and use in fibrin quantification in blood plasma.

Preparation Note

Prepared by clotting fibrinogen to yield a crosslinked fibrin

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Matthew Riopel et al.
Acta biomaterialia, 9(9), 8140-8148 (2013-06-12)
Extracellular matrix (ECM)-integrin stimulation can promote beta cell differentiation, proliferation and function. However, beta cells lose their insulin secretion function in response to glucose stimulation, and senesce when cultured with ECM proteins for a long time. Fibrin is a provisional
Kohji Kasahara et al.
Blood, 122(19), 3340-3348 (2013-09-05)
Membrane rafts are spatially and functionally heterogenous in the cell membrane. We observed that lysenin-positive sphingomyelin (SM)-rich rafts are identified histochemically in the central region of adhered platelets where fibrin and myosin are colocalized on activation by thrombin. The clot
B J De Kort et al.
Acta biomaterialia, 135, 243-259 (2021-09-13)
In situ heart valve tissue engineering is an emerging approach in which resorbable, off-the-shelf available scaffolds are used to induce endogenous heart valve restoration. Such scaffolds are designed to recruit endogenous cells in vivo, which subsequently resorb polymer and produce
Mehmet Hamdi Kural et al.
Experimental cell research, 319(16), 2447-2459 (2013-07-16)
The processes of development, repair, and remodeling of virtually all tissues and organs, are dependent upon mechanical signals including external loading, cell-generated tension, and tissue stiffness. Over the past few decades, much has been learned about mechanotransduction pathways in specialized
Craig P Fischer et al.
Journal of the American College of Surgeons, 217(3), 385-393 (2013-08-24)
This study evaluated the hemostatic effectiveness and safety of Fibrin Pad (Omrix Biopharmaceuticals Ltd.) vs absorbable hemostat in patients undergoing nonemergent surgery. Fibrin Pad is a topical absorbable hemostat designed to be effective in a variety of soft tissues and

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