Skip to Content
Merck
All Photos(1)

Key Documents

F3377

Sigma-Aldrich

N-Formyl-L-methionine

≥90% (TLC)

Synonym(s):

fMet

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C6H11NO3S
CAS Number:
Molecular Weight:
177.22
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26

Product Name

N-Formyl-L-methionine, ≥90% (TLC)

Quality Level

Assay

≥90% (TLC)

form

powder

color

white

storage temp.

−20°C

SMILES string

CSCC[C@H](NC=O)C(O)=O

InChI

1S/C6H11NO3S/c1-11-3-2-5(6(9)10)7-4-8/h4-5H,2-3H2,1H3,(H,7,8)(H,9,10)/t5-/m0/s1

InChI key

PYUSHNKNPOHWEZ-YFKPBYRVSA-N

Application

N-Formyl-L-methionine (fMet) is used to identify, differentiate and characterize amino acid N-deformylase(s), N-carbamoylase(s) and N-aminoacylase(s).

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

J Tomsic et al.
The EMBO journal, 19(9), 2127-2136 (2000-05-03)
Binding of the 50S ribosomal subunit to the 30S initiation complex and the subsequent transition from the initiation to the elongation phase up to the synthesis of the first peptide bond represent crucial steps in the translation pathway. The reactions
Dongli Pan et al.
Molecular cell, 25(4), 519-529 (2007-02-24)
Translocation requires large-scale movements of ribosome-bound tRNAs. Using tRNAs that are proflavin labeled and single-turnover rapid kinetics assays, we identify one or possibly two kinetically competent intermediates in translocation. EF-G.GTP binding to the pretranslocation (PRE) complex and GTP hydrolysis are
S W Dow et al.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 80(1), 5-13 (2000-07-18)
To determine whether synthetic peptides containing an amino terminal formyl-methionine residue and corresponding to the sequence of several proteins produced by Mycobacterium tuberculosis, would elicit an immune response in mice. Peptides corresponding to the amino termini of 8 M. tuberculosis
Simon Lind et al.
Journal of immunology (Baltimore, Md. : 1950), 202(9), 2710-2719 (2019-03-25)
Similar to bacteria, synthesis of mitochondrial DNA-encoded proteins requires an N-formylated methionine to initiate translation. Thus, the N-formylated methionine peptides originating from mitochondria should be recognized as danger signals. To date, only one such peptide, denoted as mitocryptide-2 (MCT-2), originating
Chen Bao et al.
eLife, 9 (2020-05-20)
Although the elongating ribosome is an efficient helicase, certain mRNA stem-loop structures are known to impede ribosome movement along mRNA and stimulate programmed ribosome frameshifting via mechanisms that are not well understood. Using biochemical and single-molecule Förster resonance energy transfer

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service