03907

Tioconazole

97%

• Synonym(s): 1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, Thioconazole
• Empirical Formula (Hill Notation): C₁₆H₁₃Cl₃N₂OS
• CAS Number: 65899-73-2
• Molecular Weight: 387.71
• EC Number: 265-973-8
• MDL number: MFCD00057276
• UNSPSC Code: 51302325
• PubChem Substance ID: 329747834
• NACRES: NA.85

Properties

• Assay: ≥96.5% (HPLC); 96.5-103.5% (NT); 97%
• form: powder
• color: white to off-white
• antibiotic activity spectrum: fungi; yeast
• Mode of action: cell membrane | interferes
• SMILES string: Clc1ccc(C(Cn2ccnc2)OCc3ccsc3Cl)c(Cl)c1
• InChI: 1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2
• InChI key: QXHHHPZILQDDPS-UHFFFAOYSA-N

Description

General description

Chemical structure: pyrimidine

Application

Tioconazole was used to study the synergistic mechanisms of antifungals on Candida albicans as well as significant drug-drug interactions in vivo.

Biochem/physiol Actions

Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by fungus and yeast.It is more active than fluconazole or voriconazole against Candida glabrata mutant strains. It acts by membrane disruption and loss of intracellular ATP.

Packaging

10G

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Safety Information

• Pictograms: GHS08,GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H302,H317,H361d,H410
• Precautionary Statements: P202 - P273 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves