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SMB01344

Sigma-Aldrich

N-Methyl-4-pyridone-5-carboxamide

Synonym(s):

1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide, 1,4-Dihydro-1-methyl-4-oxo-nicotinamide, 1-Methyl-1,4-dihydro-4-oxo-3-pyridinecarboxamide, 1-Methyl-4-pyridone-3-carboxamide, 1-Methyl-4-pyridone-5-carboxamide, 4-Py, 4PY, Me4PY, Met4PY, N1-Methyl-4-pyridone-3-carboxamide, N1-Methyl-4-pyridone-5-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C7H8N2O2
CAS Number:
769-49-3
Molecular Weight:
152.15
MDL number:
MFCD31726263
UNSPSC Code:
12352205
NACRES:
NA.77

Assay

≥95% (HPLC)

Quality Level

100

form

solid

InChI

1S/C7H8N2O2/c1-9-3-2-6(10)5(4-9)7(8)11/h2-4H,1H3,(H2,8,11)

InChI key

KTLRWTOPTKGYQY-UHFFFAOYSA-N

General description

N1-methyl-4-pyridone-5-carboxamide is involved in nicotinate and nicotinamide metabolism.

Application

Metabolomics research

Other Notes

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ7019

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Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.
Yoshino, et al.
Science (New York, N.Y.), 372, 1224-1229 (2021)
Aurélie Lenglet et al.
Toxins, 8(11) (2016-11-18)
N-methyl-2-pyridone-5-carboxamide (2PY, a major metabolite of nicotinamide, NAM) was recently identified as a uremic toxin. Recent interventional trials using NAM to treat high levels of phosphorus in end-stage renal disease have highlighted new potential uremic toxicities of 2PY. In the
Renata Novak Kujundžić et al.
International journal of molecular sciences, 22(11) (2021-06-03)
The activity of nicotinamide N-methyltransferase (NNMT) is tightly linked to the maintenance of the nicotinamide adenine dinucleotide (NAD+) level. This enzyme catalyzes methylation of nicotinamide (NAM) into methyl nicotinamide (MNAM), which is either excreted or further metabolized to N1-methyl-2-pyridone-5-carboxamide (2-PY)

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