81242

Poly(ethylene glycol)

tested according to Ph. Eur., 4,000

• Synonym(s): Macrogol 4,000, Polyethylene glycol, PEG
• Linear Formula: H(OCH₂CH₂)_nOH
• CAS Number: 25322-68-3
• MDL number: MFCD00081839
• UNSPSC Code: 12352104
• PubChem Substance ID: 24887707
• NACRES: NA.21

Properties

• Agency: tested according to Ph. Eur.
• Quality Level: 200
• form: solid
• mol wt: 3500-4500
• application(s): pharmaceutical (small molecule)
• SMILES string: C(CO)O
• InChI: 1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
• InChI key: LYCAIKOWRPUZTN-UHFFFAOYSA-N

Description

General description

Poly(ethylene glycol) (PEG) is a non-toxic water-soluble polymer. PEG term is used for the polymer chains with molecular weights below 20 000, while poly(ethylene oxide) (PEO) refers to the higher molecular weight polymers. PEG has various biomedical applications. It forms complexes with α-cyclodextrins. Engineering of PEG hydrogel particles by mesoporous silica (MS) templating method has been reported.

Application

Poly(ethylene glycol) may be used in the following studies:

• For the modification of proteins to form the conjugates having increased circulating life and reduced immunogenicity and antigenicity.
• Preparation of hydrogels useful for the diffusion controlled delivery of proteins.
• Preparation of poly(ethylene glycol) dimethacrylate (PEGDM).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves