Vacuolin-1, A cell-permeable triazine based compound that inhibits Ca2+-dependent fusion of lysosomes with the plasma membrane and the release of lysosomal content, without affecting enlargeosomes or other membrane-bound organelles.
A cell-permeable triazine based compound that inhibits Ca2+-dependent fusion of lysosomes with the plasma membrane and the release of lysosomal content, without affecting enlargeosomes or other membrane-bound organelles. It does not disturb the organization of the actin or tubulin cytoskeletal network, nor does it interfere with membrane traffic along the constitutive pathway from the ER to the plasma membrane.
A cell-permeable triazine-based compound that inhibits Ca2+-dependent exocytosis of lysosomes induced by ionomycin or plasma membrane wounding. Does not affect the resealing process and the exocytosis of enlargeosomes. It also does not disturb the organization of the actin or tubulin cytoskeletal network or interfere with membrane traffic along the constitutive pathway from the ER to the plasma membrane.
Biochem/physiol Actions
Cell permeable: yes
Primary Target Ca2+-dependent fusion of lysosomes with the plasma membrane
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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During tumor progression, lysosome function is often maladaptively upregulated to match the high energy demand required for cancer cell hyper-proliferation and invasion. Here, we report that mucolipin TRP channel 1 (TRPML1), a lysosomal Ca2+ and Zn2+ release channel that regulates
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