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Key Documents

575003-M

Sigma-Aldrich

α-Synuclein A53T, Human, Recombinant, E. coli

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77

Assay

≥95% (SDS-PAGE)

Quality Level

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

storage temp.

−20°C

General description

Recombinant, human α-synuclein containing an A53T mutation and expressed in E. coli. α-synuclein is an acidic neuronal protein of 140 amino acids that has been implicated in the pathogenesis of Parkinson′s disease and related neurodegenerative disorders. α-Synuclein (A53T) is a point mutant of the α-synuclein gene that has been linked to autosomal dominant early onset Parkinson′s Disease (PD). The apparent molecular weight on SDS-PAGE is ~19-20 kDa.
Recombinant, human α-synuclein containing an A53T mutation and expressed in E. coli. A point mutant (A53T) of α-synuclein gene that has been linked to autosomal dominant early-onset Parkinson’s disease (PD).

Warning

Toxicity: Standard Handling (A)

Physical form

In 100 mM NaCl, 20 mM Tris-HCl, pH 7.5.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Lashuel, H.A., et al. 2002. J. Mol. Biol.322, 1089.
Park, S.M., et al. 2002. Blood100, 2506.
Polymeropoulos, M.H., et al. 1997. Science276, 2045.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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