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840514C

Avanti

16:0-18:1 Phosphatidylethanol

Avanti Research™ - A Croda Brand 840514C

Synonym(s):

1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol (sodium salt)

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About This Item

Empirical Formula (Hill Notation):
C39H74NaO8P
CAS Number:
322647-55-2
Molecular Weight:
724.96
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (840514C-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 840514C

concentration

10 mg/mL (840514C-25mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCC)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O.[Na+]

General description

Phosphatidylethanol (PEth) is a phospholipid, that is generated in the the presence of ethanol in cell membranes. PEths like PEth 16:0/18:1, PEth 18:1/18:1, and PEth 16:0/16:0 possesses a common phosphoethanol head. Two fatty acid chains of variable length and degree of saturation are bound to this head group. It is widely distributed in gram-positive organisms.
Phosphatidylethanol (PEth) represents a group of glycerophospholipid homologues generated by substitution of ethanol for the lipid headgroup by the phospholipase D enzyme. Since the formation of PEth is specifically dependent on ethanol, the diagnostic specificity of PEth as an alcohol biomarker is theoretically 100%.

Application

16:0-18:1 Phosphatidylethanol is suitable for use in the preparation of liposomes used for permeability studies.

Biochem/physiol Actions

Phosphatidylethanols (PEths) serves as crucial biomarkers of alcohol consumption.

Packaging

5 mL Clear Glass Sealed Ampule (840514C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sigma-Aldrich

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Interactions of oritavancin, a new lipoglycopeptide derived from vancomycin, with phospholipid bilayers: effect on membrane permeability and nanoscale lipid membrane organization
Domenech O, et al.
Biochimica et Biophysica Acta - Biomembranes, 1788(9), 1832-1840 (2009)
Anders Isaksson et al.
Drug testing and analysis, 3(4), 195-200 (2011-03-26)
Phosphatidylethanol (PEth) represents a group of glycerophospholipid homologues where ethanol by phospholipase D has been bound at the position that normally contains an amino-alcohol. Since the formation of PEth is specifically dependent on ethanol, the diagnostic specificity of PEth as
David Wensbo Posaric et al.
Analytical and bioanalytical chemistry, 406(19), 4735-4744 (2014-05-29)
Various phosphatidylethanol (PEth) derivatives, the corresponding reversed positional isomers (RPI-PEths), lyso-PEth-16:0, and penta-deuterium-labeled PEth analogs (d5-PEths), were synthesized by enzyme-independent synthetic routes. A general solvent system consisting of a mixture of acetone-d6 and methanol-d4 (97:3; v/v) was found to provide
The detection of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol and ethyl glucuronide in human umbilical cord
Jones J, et al.
American Journal of Analytical Chemistry, 3(12), 800-800 (2012)
Alexandra Schröck et al.
Bioanalysis, 6(17), 2285-2294 (2014-11-11)
For early diagnosis and therapy of alcohol-related disorders, alcohol biomarkers are highly valuable. Concerning specificity, indirect markers can be influenced by nonethanol-related factors, whereas direct markers are only formed after ethanol consumption. Sensitivity of the direct markers depends on cut-offs
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