The Journal of pharmacology and experimental therapeutics, 213(2), 254-260 (1980-05-01)
A series of substituted phenylethylamines were examined for their relative potencies to 1) release and inhibit accumulation of labeled serotonin in brain synaptosomes, 2) compete with serotonin receptor binding and 3) induce the "serotonin syndrome" in mice. In general, the
The American journal of tropical medicine and hygiene, 32(1), 83-93 (1983-01-01)
Neuropharmacological studies of Schistosoma mansoni were conducted in vitro using visual observations of motor activity and measurements of worm length and extracellular electrical activity. The instrumentation and methodology described quantitatively measure extracellular electrical potentials associated with motor activity, and provide
Harmane and norharmane (two beta-carbolines) are tobacco components or products. The effects of harmane and norharmane on serotonergic raphe neurons remain unknown. Harmane and norharmane are inhibitors of the monoamine oxidases A (MAO-A) and B (MAO-B), respectively. To study the
Progress in neuro-psychopharmacology & biological psychiatry, 6(4-6), 343-346 (1982-01-01)
1. The accumulation of p-chlorophenylethylamine (pCPE) in rat brain after administration of pargyline plus p-chlorophenylalanine (pCPA) is demonstrated. 2. Measurements of pCPE in brain were performed at 0.25 h, 1 h and 4 h after administration of pCPA to pargyline-pretreated
Enzymes of intermediary metabolism are often reported to have moonlighting functions as RNA-binding proteins and have regulatory roles beyond their primary activities. Human serine hydroxymethyltransferase (SHMT) is essential for the one-carbon metabolism, which sustains growth and proliferation in normal and
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