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Sigma-Aldrich

Magnesium stearate

technical grade

Synonym(s):

Stearic acid magnesium salt

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About This Item

Linear Formula:
[CH3(CH2)16CO2]2Mg
CAS Number:
557-04-0
Molecular Weight:
591.24
Beilstein:
3919702
EC Number:
209-150-3
MDL number:
MFCD00036391
UNSPSC Code:
12352100
PubChem Substance ID:
24865972
NACRES:
NA.22

grade

technical grade

form

powder

composition

palmitate salt, 25%
stearate salt, 65%

mp

200 °C (lit.)

SMILES string

CCCCCCCCCCCCCCCCCC(=O)O[Mg]OC(=O)CCCCCCCCCCCCCCCCC

InChI

1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2

InChI key

HQKMJHAJHXVSDF-UHFFFAOYSA-L

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General description

Magnesium stearate (Mg-St) is the magnesium salt of stearic acid. Its anhydrate, dihydrate and trihydrate forms have been prepared. The tabletting of the blends of magnesium stearate and lactose granules has been described. The influence of mixing time on hardness, disintegration time and ejection force on the compressed tablets was examined. Mg-St is widely used lubricant in pharmaceutical industry. It also plays a role in delaying the process of dissolution. Its detection in tablets by laser-induced breakdown spectroscopy has been proposed.

Magnesium stearate, the salt of stearic acid, is widely employed as an inactive component in making pharmaceutical tablets.

Application

Magnesium stearate may be used as excipient in the formulations of diclofenac sodium tablets. It may be used for the preparation of tramadol HCl matrix tablets.

Storage Class Code

11 - Combustible Solids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Delay effect of magnesium stearate on tablet dissolution in acidic medium.
Ariyasu A, et al.
International Journal of Pharmaceutics, 511(2), 757-764 (2016)
Paola Bertocchi et al.
Journal of pharmaceutical and biomedical analysis, 37(4), 679-685 (2005-03-31)
The aim of this work was to compare the dissolution behaviour of six diclofenac sodium prolonged release tablets of different brands obtained from the national market. The formulations contain the same amount of drug substance but different types and/or amount
Physical characterization of the polymorphic variations of magnesium stearate and magnesium palmitate hydrate species.
Sharpe SA, et al.
Structural Chemistry, 8(1), 73-84 (1997)
Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential
Hobbs CA, et al.
Toxicology Reports, 4, 554-559 (2017)
Louis St-Onge et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 8(2), 272-288 (2005-08-30)
Laser-induced breakdown spectroscopy (LIBS) was evaluated for its potential as a process analytical tool for the rapid determination of magnesium stearate (MgSt) distribution within and between tablets as well as between batches in a typical manufacturing run, and for the
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