1605205

Ropinirole hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Synonyme(s) : 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride, SKF 101468 hydrochloride
• Formule empirique (notation de Hill) : C₁₆H₂₄N₂O · HCl
• Numéro CAS: 91374-20-8
• Poids moléculaire : 296.84
• NACRES: NA.24
• PubChem Substance ID: 329751058
• UNSPSC Code: 41116107
• MDL number: MFCD01754173

Propriétés

• grade: pharmaceutical primary standard
• agency: USP
• API family: ropinirole
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: Cl.CCCN(CCC)CCc1cccc2NC(=O)Cc12
• InChI: 1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H
• InChI key: XDXHAEQXIBQUEZ-UHFFFAOYSA-N
• Gene Information: human ... DRD2(1813), DRD3(1814), DRD4(1815)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ropinirole hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Ropinirole Extended-Release Tablets
• Ropinirole Hydrochloride
• Ropinirole Tablets

Biochem/physiol Actions

An agonist at the D₂ and D₃ dopamine receptor subtypes, binding with higher affinity to D₃ than to D₂ or D₄. It has negligible effect on D₁-receptors. It has medium in vitro affinity to opioid receptors. Ropinirole is said to have virtually no affinity to 5-HT₁, 5-HT₂, benzodiazepine, GABA, muscarinic, α1-, α2-, and β-adrenoreceptors. Used as antiparkinsonian drug.

Selective D₂ dopamine receptor agonist, antiparkinsonian

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Informations sur la sécurité

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H302,H400
• pcodes: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable