1332000

Hydroxyurée

United States Pharmacopeia (USP) Reference Standard

• Synonyme(s) : Hydroxycarbamide
• Formule linéaire : NH₂CONHOH
• Numéro CAS: 127-07-1
• Poids moléculaire : 76.05
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329750138
• MDL number: MFCD00007943
• Beilstein/REAXYS Number: 1741548

Propriétés

• grade: pharmaceutical primary standard
• agency: USP
• API family: hydroxyurea
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule); pharmaceutical
• format: neat
• storage temp.: 2-8°C
• SMILES string: NC(=O)NO
• InChI: 1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
• InChI key: VSNHCAURESNICA-UHFFFAOYSA-N
• Gene Information: human ... RRM1(6240), RRM2(6241), RRM2B(50484)

Description

General description

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This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Anti-néoplasique. Inactive la ribonucléoside réductase par formation d′un radical libre nitroxyde qui se lie à un radical libre tyrosyle sur le site actif de l′enzyme. Ceci bloque la synthèse des désoxynucléotides, ce qui inhibe la synthèse d′ADN et induit la synchronisation ou la mort cellulaire en phase S.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mot-clé: Danger
• Codes de danger: H340,H361
• Mentions de précaution: P201 - P280 - P308 + P313
• Hazard Classifications: Muta. 1B - Repr. 2
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable