1148089

Collagénase from Clostridium histolyticum

United States Pharmacopeia (USP) Reference Standard

• Synonyme(s) : Clostridiopeptidase A
• Numéro CAS: 9001-12-1
• UNSPSC Code: 41116107
• NACRES: NA.24
• Numéro CE : 3.4.24.3 (BRENDA, IUBMB)
• MDL number: MFCD00130830

Propriétés

• grade: pharmaceutical primary standard
• agency: USP
• form: liquid
• manufacturer/tradename: USP
• application(s): USP Biologics; pharmaceutical
• format: neat

Description

General description

Collagenase I is an enzyme that breaks down collagen, a primary structural protein in connective tissues. It is used in various medical and research applications, including tissue dissociation and wound debridement.​

The USP Collagenase I standard provides a benchmark for the activity and purity of collagenase I, ensuring its efficacy and safety in therapeutic and laboratory settings.

The USP biologics proteins category provides critical standards and reference materials necessary for the development and manufacturing of therapeutic proteins. These proteins, which can be naturally derived or genetically engineered, are essential in treating various diseases and conditions, ensuring that they meet quality, safety, and efficacy standards.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

Biochem/physiol Actions

La collagénase est activée à l′aide de quatre atome-grammes de calcium par mole d′enzyme. Elle est inhibée par l′acide éthylèneglycol-bis(bêta-aminoéthyléther)-N,N,N′,N′-tétraacétique, le bêta-mercaptoéthanol, le glutathion, l′acide thioglycolique et la 8-hydroxyquinoline.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Une unité de digestion de collagène (UDC) libère une quantité de peptides à partir du collagène d′un tendon d′Achille de bovin équivalant, en termes de couleur avec la méthode à la ninhydrine, à 1,0 μmole de leucine en 5 heures à pH 7,4 et à 37 °C en présence d′ions calcium. Une unité d′hydrolyse de FALGPA hydrolyse 1,0 μmole de furylacryloyl-Leu-Gly-Pro-Ala par minute à 25 °C. Une unité de protéase neutre hydrolyse la caséine et produit une couleur équivalente à 1,0 μmole de tyrosine en 5 heures à pH 7,5 et à 37 °C. Une unité de clostripaïne hydrolyse 1,0 μmole de BAEE par minute à pH 7,6 et à 25 °C en présence de DTT.

Sales restrictions may apply.

This product is part of the USP Biologics program.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Informations sur la sécurité

• pictograms: GHS08
• signalword: Danger
• hcodes: H334
• pcodes: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Classe de stockage: 12 - Non Combustible Liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable