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Z103

Sigma-Aldrich

Zolpidem

≥98% (HPLC), solid, benzodiazepine receptor agonist

Synonyme(s) :

N,N,6-Trimethyl-2-(4-methylphenyl)-imidazo[1,2-a]pyridine-3-acetamide

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About This Item

Formule empirique (notation de Hill):
C19H21N3O
Numéro CAS:
82626-48-0
Poids moléculaire :
307.39
Numéro MDL:
MFCD00153885
Code UNSPSC :
12352200
ID de substance PubChem :
24902172
Nomenclature NACRES :
NA.77

product name

Zolpidem, ≥98% (HPLC), solid

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

solid

Contrôle du médicament

USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

Couleur

white

Solubilité

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL
DMSO: >10 mg/mL
ethanol: 50 mg/mL
methanol: 50 mg/mL
H2O: insoluble
dilute aqueous base: insoluble

Auteur

Sanofi Aventis

Chaîne SMILES 

CC1=CN2C(C=C1)=NC(C3=CC=C(C)C=C3)=C2CC(N(C)C)=O

InChI

1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3

Clé InChI

ZAFYATHCZYHLPB-UHFFFAOYSA-N

Informations sur le gène

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRG2(2566)
rat ... Gabra1(29705) , Gabra2(29706) , Gabra5(29707) , Tspo(24230)

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Actions biochimiques/physiologiques

Potent and selective agonist for the benzodiazepine receptor associated with the GABAA receptor; hypnotic.

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Exclamation markEnvironment
GHS07,GHS09

Mention d'avertissement

Warning

Mentions de danger

H302,H336,H411

Classification des risques

Acute Tox. 4 Oral - Aquatic Chronic 2 - STOT SE 3

Organes cibles

Central nervous system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Thomas Chao et al.
Drug and alcohol dependence, 185, 23-32 (2018-02-08)
Stress responding is linked to drug use, but little is known about stress responses in cannabis smokers. We investigated acute stress responding in cannabis smokers as a function of trauma exposure and sex, and relationships between stress responses and cannabis
Ming-May Lai et al.
Mayo Clinic proceedings, 89(5), 589-594 (2014-04-02)
To estimate the risk of head injury or fracture requiring hospitalization in patients treated with zolpidem. We identified 8188 patients 18 years and older who had received a first prescription for zolpidem between January 1, 2000, and December 31, 2009
Megan J Shram et al.
Journal of clinical psychopharmacology, 40(6), 568-578 (2020-10-22)
Human abuse potential studies include multiple measures to assess the subjective effects of central nervous system-active drugs. In this retrospective analysis, measurement properties of commonly used measures were assessed, and factor analysis was conducted to identify a core battery of
Eunmi Kim et al.
Forensic science international, 269, 50-55 (2016-11-21)
The southern area of South Korea consists of three parts; Busan, Ulsan and Gyeongsangnam-do. Busan Institute of National Forensic Service (NFS) performed about 50,000 cases throughout the southern area in 2014, occupying over 15% of total cases covered by NFS.
Cheng-Tai Li et al.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 12(11), 1453-1459 (2016-08-30)
The present single-dose, parallel-group, randomized, double-blind, placebo-controlled study is to evaluate the pharmacokinetics, tolerability and safety of zolpidem tartrate nasal spray (ZNS) as compared to placebo in healthy subjects. Thirty-six healthy subjects participated in this study, with 19 male and
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