T123

Thioperamide maleate salt

≥98% (HPLC), histamine H3 receptor antagonist, solid

• Synonyme(s) : MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt
• Formule empirique (notation de Hill) : C₁₅H₂₄N₄S · C₄H₄O₄
• Numéro CAS: 148440-81-7
• Poids moléculaire : 408.52
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277809
• NACRES: NA.77
• MDL number: MFCD00083209
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated, under inert gas

Propriétés

• Nom du produit: Thioperamide maleate salt, solid
• assay: ≥98% (HPLC)
• Quality Segment: 200
• form: solid
• storage condition: desiccated, under inert gas
• color: white
• solubility: H₂O: >10 mg/mL, DMSO: 12 mg/mL, ethanol: 3 mg/mL
• SMILES string: OC(=O)\C=C/C(O)=O.S=C(CC1CCCCC1)N2CCC(CC2)c3c[nH]cn3
• InChI: 1S/C16H25N3S.C4H4O4/c20-16(10-13-4-2-1-3-5-13)19-8-6-14(7-9-19)15-11-17-12-18-15;5-3(6)1-2-4(7)8/h11-14H,1-10H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChI key: REZRBLGMJZZSID-BTJKTKAUSA-N
• Gene Information: human ... HRH3(11255)

Description

Application

Thioperamide maleate salt was used to study the sympathetic and autonomic nerve activity in mammalian white adipose tissue.

Biochem/physiol Actions

Potent and selective H₃ histamine receptor antagonist that crosses the blood-brain barrier.

Thioperamide is a potent and selective H₃ histamine receptor antagonist that crosses the blood-brain barrier. It affects the central histaminergic system and decreases the duration of seizures and convulsions in mice. It also improves learning deficit induced by other drugs such as scopolamine.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves