SML3098

C-178

≥98% (HPLC)

• Synonyme(s) : C 178, C178, N-(Dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide, N-3-Dibenzofuranyl-5-nitro-2-furancarboxamide, N-Dibenzofuran-3-yl-5-nitrofuran-2-carboxamide
• Formule empirique (notation de Hill) : C₁₇H₁₀N₂O₅
• Numéro CAS: 329198-87-0
• Poids moléculaire : 322.27
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD01146392
• Assay: ≥98% (HPLC)
• Form: powder

Propriétés

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: faint yellow to dark brown
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC(OC3=C4C=CC=C3)=C4C=C2
• InChI key: URUVDCCYSJEGQQ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

C-178 is a potent and selective inhibitor against murine, but not human, stimulator of interferon genes (STING) via covalent modifiation of mSTING Cys91. C-178 inhibits mSTING-mediated IFNβ reporter activity (IC50 <500 nM) without affecting RIG-I, and blocks (0.5 μM) downstream TBK1 phosphorylation induction by STING agonist CMA (1.4 h) in mSTING-expressing HEK293T cells.

Potent and selective, Cys91-targeting covalent inhibitor against murine, but not human, STING.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable