SML2615

Ixabepilone

≥98% (HPLC)

• Synonyme(s) : (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione, Azaepothilone B, BMS-247550, NSC-710428
• Formule empirique (notation de Hill) : C₂₇H₄₂N₂O₅S
• Numéro CAS: 219989-84-1
• Poids moléculaire : 506.70
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD04307791
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: protect from light

Propriétés

• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -35 to -45°, c = 1.0 in chloroform-d
• storage condition: protect from light
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: [s]1c(nc(c1)\C=C(\[C@H]2NC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]([C@H](CCC[C@]3(O[C@H]3C2)C)C)O)C)(C)C)O)/C)C
• InChI: 1S/C27H42N2O5S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)29-23(31)13-21(30)26(5,6)25(33)17(3)24(15)32/h11,14-15,17,20-22,24,30,32H,8-10,12-13H2,1-7H3,(H,29,31)/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
• InChI key: FABUFPQFXZVHFB-PVYNADRNSA-N

Description

Biochem/physiol Actions

Ixabepilone is a microtubule stabilizing semisynthetic lactam analog of epothilone B. It appears that Ixabepilone is unaffected by BCRP mediated chemoresistance.

Microtubule stabilizing agent that is unaffected by BCRP mediated chemoresistance

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mot-clé: Danger
• Codes de danger: H301,H341,H361fd,H372
• Mentions de précaution: P202 - P260 - P264 - P280 - P301 + P310 - P405
• Hazard Classifications: Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1
• Organes cibles: Gastro-intestinal system,hematopoietic system,Nervous system,lymphatics
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable