SML2559

C-176

≥98% (HPLC)

• Synonyme(s) : C 176, C176, N-(4-Iodophenyl)-5-nitro-2-furancarboxamide, N-(4-Iodophenyl)-5-nitrofuran-2-carboxamide, Sting inhibitor 1, Sting inhibitor C-176
• Formule empirique (notation de Hill): C₁₁H₇IN₂O₄
• Numéro CAS: 314054-00-7
• Poids moléculaire : 358.09
• Numéro MDL: MFCD00784208
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to very dark gray
• Solubilité: DMSO: 2 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C(NC1=CC=C(I)C=C1)C2=CC=C([N+]([O-])=O)O2

Description

Actions biochimiques/physiologiques

C-176 is a potent and selective inhibitor against murine, but not human, stimulator of interferon genes (STING) via covalent modifiation of mSTING Cys91. C-176 inhibits STING-mediated IFNβ reporter activity (IC₅₀ <50 nM) without affecting RIG-I, and blocks (1 μM) downstream TBK1 phosphorylation induction by STING agonist CMA (1.4 h) in mSTING-expressing HEK293T cells. C-176 markedly reduces CMA-induced serum IL-6 & type I IFNs in mice (by ≥85% 4 h post CMA; 750 nmol C-176/mouse i.p. 1 or 4 h prior to 224 mg/kg CMA) and significantly ameliorates the autoinflammatory severity in Trex1−/− mice.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable