SML1760

BAM15

≥98% (HPLC), powder, mitochondrial protonophore uncoupler

• Synonyme(s) : BAM 15, N5,N6-bis(2-Fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
• Formule empirique (notation de Hill) : C₁₆H₁₀F₂N₆O
• Numéro CAS: 210302-17-3
• Poids moléculaire : 340.29
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00373912
• Assay: ≥98% (HPLC)
• Form: powder

Propriétés

• Nom du produit: BAM15, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: FC(C=CC=C1)=C1NC2=NC3=NON=C3N=C2NC4=CC=CC=C4F
• InChI: 1S/C16H10F2N6O/c17-9-5-1-3-7-11(9)19-13-14(20-12-8-4-2-6-10(12)18)22-16-15(21-13)23-25-24-16/h1-8H,(H,19,21,23)(H,20,22,24)
• InChI key: OEGJBRZAJRPPHL-UHFFFAOYSA-N

Description

Biochem/physiol Actions

BAM15 is a cell penetrant and potent uncoupler of oxidative phosphorylation in mitochondria that that does not depolarizes the plasma membrane. BAM15 protects mice from acute renal ischemic-reperfusion injury.

BAM15 is a cell penetrant and potent uncoupler of oxidative phosphorylation in mitochondria.

BAM15 increases mitochondrial respiration rate and is also found to be less cytotoxic compared to other protonophore uncouplers such as carbonyl cyanide p-trifluoromethoxyphenylhydrazone. Hindered oncogenic MAPK (mitogen-activated protein kinase ) signaling leads to BAM15 induced mitochondrial apoptotic pathway activation.

Informations sur la sécurité

• Codes de danger: H413
• Mentions de précaution: P273 - P501
• Hazard Classifications: Aquatic Chronic 4
• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable