SML1558
Yoda1
≥98% (HPLC), powder, Piezo1 agonist
Synonyme(s) :
2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-pyrazine
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About This Item
Formule empirique (notation de Hill):
C13H8Cl2N4S2
Numéro CAS:
Poids moléculaire :
355.27
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77
Produits recommandés
product name
Yoda1, ≥98% (HPLC)
Niveau de qualité
Pureté
≥98% (HPLC)
Forme
powder
Couleur
white to beige
Solubilité
DMSO: 15 mg/mL, clear
Température de stockage
2-8°C
Description générale
Yoda1 is a novel synthetic small molecule developed to study the kinetics, regulation and function of the cation channel Piezo-type mechanosensitive ion channel component 1 (Piezo1).
Application
Yoda1 has been used to investigate its effect on heterotrimeric Piezo1 channels.
Actions biochimiques/physiologiques
Yoda1 is a specific activator of mouse and human cation channel Piezo1, a mechanosensitive channel that mediates Ca2+ influx on mechanical activation and has been linked to a role in blood vessel development. Yoda1 stabilizes the Piezo1 open channel. In red blood cells, this was followed by downstream activation of the KCa3.1 Gardos channel with resultant calcium influx and potassium and water efflux, causing shrinkage of the cells. Yoda1 is the first Piezo1 agonist, giving the first evidence of non-mechanical activation of a Piezo channel.
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 4 Oral
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Chemical gating of the mechanosensitive Piezo1 channel by asymmetric binding of its agonist Yoda1.
Lacroix JJ, et al.
bioRxiv, 169516-169516 (2017)
Jerome J Lacroix et al.
Nature communications, 9(1), 2029-2029 (2018-05-26)
Piezo proteins are transmembrane ion channels which transduce many forms of mechanical stimuli into electrochemical signals. Their pore, formed by the assembly of three identical subunits, opens by an unknown mechanism. Here, to probe this mechanism, we investigate the interaction
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Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
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