SML1403

IN-1130

≥98% (HPLC)

• Synonyme(s) : 3-[[5-(6-Methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]-benzamide, IN 1130
• Formule empirique (notation de Hill) : C₂₅H₂₀N₆O
• Numéro CAS: 868612-83-3
• Poids moléculaire : 420.47
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Propriétés

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [nH]1c(nc(c1c4cc5nccnc5cc4)c3nc(ccc3)C)Cc2cc(ccc2)C(=O)N
• InChI: 1S/C25H20N6O/c1-15-4-2-7-20(29-15)24-23(17-8-9-19-21(14-17)28-11-10-27-19)30-22(31-24)13-16-5-3-6-18(12-16)25(26)32/h2-12,14H,13H2,1H3,(H2,26,32)(H,30,31)
• InChI key: RYKSGWSKILPDDY-UHFFFAOYSA-N

Description

Biochem/physiol Actions

IN-1130 is a potent inhibitor of the activin receptor-like kinase ALK-5 (Type 1 TGFβ1 recptor).

IN-1130 is a potent inhibitor of the activin receptor-like kinase ALK-5 (Type 1 TGF1β recptor). The compound inhibits phosphorylation of Smad-2 with an IC₅₀ of 36 nM. IN-1130 inhibits renal fibrosis, and also reduces tumor volume in prostate tumor xenografts in murine models.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mot-clé: Warning
• Codes de danger: H302
• Mentions de précaution: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable