SML1234

HAMNO

≥98% (HPLC)

• Synonyme(s) : (1Z)-1-[(2-Hydroxyanilino)methylidene]naphthalen-2-one, 1-[[(2-Hydroxyphenyl)imino]methyl]-2-naphthalenol, CID 6335338, MLS000737724, NS C111847, NSC111847
• Formule empirique (notation de Hill) : C₁₇H₁₃NO₂
• Numéro CAS: 138736-73-9
• Poids moléculaire : 263.29
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Propriétés

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: yellow to orange
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: N(c3c(cccc3)O)\C=C1\c2c(cccc2)C=CC\1=O
• InChI key: NADCEWZYITXLKJ-KAMYIIQDSA-N

Description

Biochem/physiol Actions

HAMNO is a potent and selective inhibitor of replication protein A (RPA) interactions with proteins involved in the replication stress response. HAMNO binds the N-terminal domain of RPA70 and inhibits both ATR autophosphorylation and phosphorylation of RPA32 Ser33 by ATR. HAMNO enhances DNA replication stress in cancer cells and slow tumor growth in vivo.

HAMNO is a potent and selective inhibitor of replication protein A (RPA) interactions.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable