SML0445

Clemastine fumarate salt

≥98% (HPLC), antihistamine H1-antagonist, powder

• Synonyme(s) : (+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt, (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt, 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt, 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt, Meclastine fumarate salt, Mecloprodine
• Formule empirique (notation de Hill) : C₂₁H₂₆ClNO · C₄H₄O₄
• Numéro CAS: 14976-57-9
• Poids moléculaire : 459.96
• NACRES: NA.77
• PubChem Substance ID: 329824727
• UNSPSC Code: 12352200
• EC Number: 239-055-2
• MDL number: MFCD00137486
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Propriétés

• Nom du produit: Clemastine fumarate salt, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D +15 to +25°, c = 1 in methanol
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 5 mg/mL (clear solution; warmed)
• storage temp.: room temp
• SMILES string: OC(=O)\C=C\C(O)=O.CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3
• InChI: 1S/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1
• InChI key: PMGQWSIVQFOFOQ-YKVZVUFRSA-N
• Gene Information: human ... HRH1(3269)

Description

General description

Clemastine fumarate is used to treat multiple sclerosis, sneezing and rhinorrhea linked to common cold. It stimulates oligodendrocyte progenitor cell (OPC) differentiation and myelination.

Application

Clemastine fumarate salt has been used as a stimulator of rodent oligodendrocyte generation and myelination in vitro and in vivo.

Biochem/physiol Actions

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic that also has antipruritic activity.

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable