SML0417

Costunolide

≥97% (HPLC)

• Formule empirique (notation de Hill): C₁₅H₂₀O₂
• Numéro CAS: 553-21-9
• Poids moléculaire : 232.32
• Numéro MDL: MFCD00210262
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825412
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥97% (HPLC)
• Forme: powder
• Activité optique: [α]/D +110.0 to +130.0°, c = 0.5 in chloroform-d
• Couleur: white to beige
• Solubilité: DMSO: 10 mg/mL (clear solution)
• Température de stockage: −20°C
• Chaîne SMILES: C\C1=C/CC\C(C)=C\[C@H]2OC(=O)C(=C)[C@@H]2CC1
• InChI: 1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5+,11-9+/t13-,14+/m0/s1
• Clé InChI: HRYLQFBHBWLLLL-AHNJNIBGSA-N

Description

Description générale

Costunolide has anti-ulcer and antipyretic properties. It inhibits the cellular proliferation of melanin, human lamin-B by farnesyl-protein transferase (FPTase) and protein tyrosine phosphatase 1B (hPTP1B). Costunolide has strong larvicidal activity against A.albopictus. It inhibits the expression of inducible nitric oxide synthase and DNA-binding activity of nuclear factor kappa B subunit (NF-κB). It might function as a natural herbicide.

Application

Costunolide has been used to study its effects in allergic asthma using female Balb/c mice and rat basophilic leukemia (RBL)-2H3 mast cells.

Actions biochimiques/physiologiques

Costunolide is a sesquiterpene lactone originally isolated from plants widely used in many herbal medicines. It has a variety of effects. Costunolide is a potent inducer of apoptosis, a potent anti-cancer agent, has anti-inflammatory, anti-viral, anti-fungal, antimycobacterial activity and has been shown to inhibit telomerase activity.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H317
• Conseils de prudence: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Classification des risques: Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable