SML0330

S3I-201

≥97% (HPLC)

• Synonyme(s) : 2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid, NSC 74859
• Formule empirique (notation de Hill): C₁₆H₁₅NO₇S
• Numéro CAS: 501919-59-1
• Poids moléculaire : 365.36
• Numéro MDL: MFCD09907564
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825335
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: >10 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc2ccc(C(O)=O)c(O)c2
• InChI: 1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
• Clé InChI: HWNUSGNZBAISFM-UHFFFAOYSA-N

Description

Application

S3I-201 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:

• to confirm the role of STAT3 phosphorylation in interleukin (IL)-33 production in lung epithelial cells and IL-22 mRNA expression in sorted group 3 innate lymphoid cells (ILC3s)
• to study the cellular response of STAT3 triggered by β-hexaclorocyclohexane (β-HCH) in various cell lines
• to examine the influence of STAT3 in response to angiotensin II (ang II) on induction of fibrotic proteins in kidney epithelial cells

Actions biochimiques/physiologiques

Inhibition of signal transducer and activator of transcription 3 (STAT3) activity by S3I-201 may be a potential therapeutic strategy for hypertensive kidney disease.

S3I-201 is a cell-permeable Stat3 inhibitor that binds to the Stat3-SH2 domain, prevents Stat3 phosphorylation/activation, dimerization, and DNA-binding.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable