SML0029

Glycopyrrolate

≥98% (HPLC)

• Synonyme(s) : α-cyclopentylmandelic acid ester with 3-hydroxy-1,1-dimethylpyrrolidinium bromide, 1-methyl-3-pyrrolidyl α-cyclopentylmandelate methobromide, 1-methyl-3-pyrrolidyl α-phenyl-α-cyclopentylglycolate methobromide, 3-(2-phenyl-2-cyclopentylglycoloyloxy)-1,1-dimethylpyrrolidinium bromide, 3-hydroxy-1,1-dimethylpyrrolidinium bromide α-cyclopentylmandelate, AHR-504, Copyrrolate, Gastrodyn, NSC 250836, NSC 251251, NSC 251252, NVA-237, glycopyrronium bromide
• Formule empirique (notation de Hill) : C₁₉H₂₈NO₃ · Br
• Numéro CAS: 596-51-0
• Poids moléculaire : 398.33
• NACRES: NA.77
• PubChem Substance ID: 329825100
• UNSPSC Code: 12352200
• EC Number: 209-887-0
• MDL number: MFCD00072137
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Propriétés

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: H₂O: ≥24 mg/mL
• originator: Novartis
• storage temp.: 2-8°C
• SMILES string: [Br-].C[N+]1(C)CCC(C1)OC(=O)C(O)(C2CCCC2)c3ccccc3
• InChI: 1S/C19H28NO3.BrH/c1-20(2)13-12-17(14-20)23-18(21)19(22,16-10-6-7-11-16)15-8-4-3-5-9-15;/h3-5,8-9,16-17,22H,6-7,10-14H2,1-2H3;1H/q+1;/p-1
• InChI key: VPNYRYCIDCJBOM-UHFFFAOYSA-M
• Gene Information: human ... CHRM1(1128), CHRM3(1131)

Description

General description

Glycopyrrolate is a quaternary ammonium compound and it shows structural similarity with atropine.

Biochem/physiol Actions

Glycopyrrolate is long-acting muscarinic antagonist (LAMA). It is kinetically selective muscarinic M3 receptor antagonist.

Long-acting muscarinic antagonist (LAMA); anticholinergic; antispasmodic; preanesthetic medicant

Glycopyrrolate is an anti-cholinergic drug. It is a potent controller of drooling, observed in children affected with cerebral palsy. Compared to other muscarinic antagonists, glycopyrrolate has lower CNS (central nervous system) penetration.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mot-clé: Warning
• Codes de danger: H302,H319
• Mentions de précaution: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Classe de stockage: 11 - Combustible Solids
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2