SCP0148

Furin Inhibitor II Peptide

≥95% (HPLC), lyophilized powder

• Synonyme(s) : Hexa-D-arginine amide
• Formule empirique (notation de Hill) : C₃₆H₇₅N₂₅O₆
• Poids moléculaire : 954.14
• UNSPSC Code: 12352202
• NACRES: NA.32

Propriétés

• Nom du produit: Furin Inhibitor II,
• assay: ≥95% (HPLC)
• form: lyophilized
• composition: Peptide Content, ≥48%
• storage condition: protect from light
• technique(s): protein extraction: suitable
• input: mammalian sample(s)
• storage temp.: −20°C

Description

General description

Furin is a calcium-dependent serine endoproteinase and belongs to the subtilisin-like proprotein/prohormone convertase (PC) family. It is distributed ubiquitously and has a rhythmic movement between the trans-Golgi network, cell surface and the endosomes.

Application

Furin Inhibitor II has been used as a furin inhibitor:

• to study its effects on transforming growth factor β1 (TGF-β1) induced glial cell line-derived neurotrophic factor (GDNF) production in non-tumorigenic immortalized human granulosa cell line (SVOG).
• to study its effect on cleavage of (Pro) renin receptor (PRR) induced by bovine serum albumin (BSA) in human kidney 2 (HK-2) cells.
• in furin cleavage assay.

Biochem/physiol Actions

Furin plays a role in processing several pro-proteins such as, bone morphogenetic protein 4 (BMP-4), insulin receptor and Notch1 receptor. It also processes human immune deficiency virus 1 (HIV-1) glycoprotein gp160, several metalloproteases and pro-β-nerve growth (pro-β-NGF) factor. Furin is also involved in cleaving transforming growth factor β1 (TGF-β1).

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable