S4944

Monoclonal Anti-Sonic Hedgehog (N-terminal) antibody produced in rat

clone 171018, purified immunoglobulin, lyophilized powder

• Synonyme(s) : Anti-Shh
• Numéro MDL: MFCD06798717
• Code UNSPSC : 51111800
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rat
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: 171018, monoclonal
• Forme: lyophilized powder
• Espèces réactives: human, mouse
• Technique(s): capture ELISA: suitable; immunohistochemistry (frozen sections): 25 μg/mL using mouse embryo; neutralization: suitable; western blot: 1-2 μg/test
• Isotype: IgG2a
• Numéro d'accès UniProt: Q15465
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... SHH(6469) ; mouse ... Shh(20423)

Description

Immunogène

purified, E. coli-derived, recombinant mouse sonic hedgehog N-terminal peptide (amino acids 25-198).

Actions biochimiques/physiologiques

Shh protein is secreted by Purkinje cells in the cerebellum with both autocrine and paracrine functions. The Shh signaling is mediated by the interaction of Shh with transmembrane proteins, Patched and Smoothened. The Shh pathway cross-talks Notch and Wnt pathways and acts via downstream targets such as cyclins, gamma catenin, myc and other transcription factors. The Hh family members have multiple roles as morphogens, cell survival factors, setting anterior-posterior axis and digit formation during development of limb and axon guidance factors during the development of brain and nervous system.

Forme physique

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)