S3378

Spironolactone

97.0-103.0% (HPLC), powder, aldosterone receptor antagonist

• Synonyme(s) : 4-Pregnen-21-oic acid-17α-ol-3-one-7α-thiol γ-lactone 7-acetate, 7α-(Acetylthio)-17α-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone
• Formule empirique (notation de Hill) : C₂₄H₃₂O₄S
• Numéro CAS: 52-01-7
• Poids moléculaire : 416.57
• NACRES: NA.77
• PubChem Substance ID: 24277736
• UNSPSC Code: 51111800
• EC Number: 200-133-6
• MDL number: MFCD00082250
• Assay: 97.0-103.0%

Propriétés

• Nom du produit: Spironolactone, 97.0-103.0%
• Quality Segment: 200
• assay: 97.0-103.0%
• mp: 207-208 °C (lit.)
• solubility: chloroform: complete 50 mg/ml, clear, faintly yellow
• SMILES string: CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]45CCC(=O)O5)[C@H]13
• InChI: 1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1
• InChI key: LXMSZDCAJNLERA-ZHYRCANASA-N
• Gene Information: human ... HSD17B1(3292), NR3C2(4306) ; rat ... Ar(24208)

Description

Application

Spironolactone was added to rat diet to study the effect of long-term spironolactone use on renal function.

Biochem/physiol Actions

Spironolactone is a competitive aldosterone receptor antagonist. Used as potassium sparing diuretic.

Spironolactone reduces aldosterone-induced potassium/magnesium loss and myocardial fibrosis. It reduces hypertension, improves the endothelial function and reduces the overall morbidity and mortality in patients with chronic heart failure. Spironolactone improves nitric oxide bioactivity and vascular endothelial vasodilator dysfunction.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Spironolactone yields clear, faint yellow solution in chloroform at 50 mg/ml.

Informations sur la sécurité

• pictograms: GHS08
• signalword: Danger
• hcodes: H351,H360FD,H373
• pcodes: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 2 - Repr. 1B - STOT RE 2
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P2 (EN 143) respirator cartridges