S153

SQ 22536

≥97% (HPLC), Adenylate cyclase inhibitor, powder

• Synonyme(s) : 9-(Tetrahydro-2-furanyl)-9H-purin-6-amine, 9-THF-Ade
• Formule empirique (notation de Hill) : C₉H₁₁N₅O
• Numéro CAS: 17318-31-9
• Poids moléculaire : 205.22
• UNSPSC Code: 41106305
• PubChem Substance ID: 24278057
• NACRES: NA.77
• MDL number: MFCD00210216
• Assay: ≥97% (HPLC)
• Form: powder

Propriétés

• Nom du produit: SQ 22,536, ≥97% (HPLC), powder
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: >10 mg/mL, H₂O: insoluble
• SMILES string: Nc1ncnc2n(cnc12)C3CCCO3
• InChI: 1S/C9H11N5O/c10-8-7-9(12-4-11-8)14(5-13-7)6-2-1-3-15-6/h4-6H,1-3H2,(H2,10,11,12)
• InChI key: UKHMZCMKHPHFOT-UHFFFAOYSA-N
• Gene Information: human ... ADCY1(107), ADCY2(108), ADCY3(109), ADCY4(196883), ADCY5(111), ADCY6(112), ADCY7(113), ADCY8(114), ADCY9(115) ; rat ... Adora1(29290), Adora2a(25369)

Description

Application

SQ 22,536 was used to study the role of adenylate cyclase in differentiation of PC12 cells and in gap junctional intercellular communication in breast cancer cells.

Biochem/physiol Actions

SQ 22,536 is a cell-permeable adenylyl cyclase inhibitor. IC₅₀ = 20 μM in detergent-dispersed rat brain preparation.

SQ 22,536 is an effective inhibitor of not only basal but also prosptaglandin E1-activated adenylate cyclase activities in platelets.¹ It reverses hyperalgesia contralaterally and ipsilaterally when injected intramuscularly in rats.²

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves