PRS3463
Anti-Caspase-1 (ab2) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonyme(s) :
Anti-Caspase 1, apoptosis-related cysteine peptidase (Interleukin 1, beta, convertase), Anti-ICE, Anti-IL-1β converting enzyme
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A propos de cet article
NACRES:
NA.41
UNSPSC Code:
12352203
Technique(s):
western blot: suitable, immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable
Conjugate:
unconjugated
Application:
ELISA (i), IF, IHC, WB
Citations:
3
Service technique
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rabbit
Quality Segment
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
western blot: suitable, immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CASP1(834)
General description
Caspase-1 is also known as interleukin-1βconverting enzyme (ICE). It is located on chromosome 11q22.2. It has 10 exons, an N terminal CARD (caspase activation and recruitment domain), a large P20 subunit and a small P10 subunit. It is present in leukocytes, monocytes and epithelial cells.
Immunogen
a 15 amino acid peptide from near the middle of human Caspase-1.
Biochem/physiol Actions
Caspase-1 can transform the pro-inflammatory cytokines, interleukin-1β (IL-1β) and IL-18 into their active forms. It participates in pyroptosis. It is overexpressed in the aorta of coronary atherosclerosis patients.It helps in host cell survival by inducing membrane biogenesis to restore the impairment caused by pore-forming toxins.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3463.
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Classe de stockage
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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