N5755

β-Nicotinamid-adenin-dinucleotid-phosphorsäure hydrate

• Synonyme(s) : β-NADP, Coenzyme II, NADP, TPN, Triphosphopyridinnucleotid
• Formule empirique (notation de Hill): C₂₁H₂₈N₇O₁₇P₃ · xH₂O
• Numéro CAS: 53-59-8
• Poids moléculaire : 743.41 (anhydrous basis)
• Numéro MDL: MFCD10567218
• Code UNSPSC : 41106305
• ID de substance PubChem : 24897747
• Nomenclature NACRES : NA.51

Propriétés

• Pureté: ≥95% (HPLC); ≥95% (spectrophotometric assay)
• Niveau de qualité: 200
• Forme: powder
• Solubilité: H₂O: soluble 50 mg/mL, clear, colorless to faintly yellow
• Traces de cations: sodium and potassium: ≤0.04%
• Température de stockage: −20°C
• Chaîne SMILES: O.NC(=O)c1ccc[n+](c1)[C@@H]2O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(O)=O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O
• InChI: 1S/C21H28N7O17P3.H2O/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39);1H2/t10-,11-,13-,14-,15-,16-,20-,21-;/m1./s1
• Clé InChI: ZKJOXOJMGXFSPF-QYZPTAICSA-N

Description

Application

β-Nicotinamide adenine dinucleotide phosphate hydrate is suitable for use in:

• the measurement of Glucose-6-phosphate dehydrogenase activity
• the Cytochrome P450 3A4 assay as a part of NADPH-regenerating system
• the Cytochrome P450 2D6 assay as a part of NADPH-regenerating system
• the determination of Glucose-6-phosphate content

Actions biochimiques/physiologiques

β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP).

Electron acceptor

Autres remarques

Packaged based on solid weight.

This is a common form of NADP.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves