N3136

Naltrexone hydrochloride

≥99% (HPLC), powder, opioid receptor antagonist

• Synonyme(s) : Naltrexone HCl
• Formule empirique (notation de Hill): C₂₀H₂₃NO₄ · HCl
• Numéro CAS: 16676-29-2
• Poids moléculaire : 377.86
• Numéro Beilstein : 3580333
• Numéro CE : 240-723-0
• Numéro MDL: MFCD00069324
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278051
• Nomenclature NACRES : NA.77

Propriétés

• product name: Naltrexone hydrochloride,
• Forme: powder
• Auteur: Novartis
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC6CC6
• InChI: 1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1
• Clé InChI: RHBRMCOKKKZVRY-ITLPAZOVSA-N
• Informations sur le gène: human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988) , OPRS1(10280)

Description

Application

Naltrexone hydrochloride has been used:

• as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model
• to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model
• in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22

Actions biochimiques/physiologiques

Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.

Caractéristiques et avantages

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves