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M9035

Sigma-Aldrich

IgG1, Kappa from murine myeloma

clone MOPC 31C, purified immunoglobulin, buffered aqueous solution

Synonyme(s) :

Mouse IgG1-κ

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About This Item

Numéro MDL:
MFCD00164798
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46

Source biologique

mouse

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Clone

MOPC 31C, monoclonal

Pureté

≥95% (gel filtration, HPLC)

Forme

buffered aqueous solution

Concentration

≥1 mg/mL

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

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Description générale

Immunoglobulins (Igs) belongs to the immunoglobulin super-family. IgG is the abundant immunoglobulin in human serum. The four classes of IgG can be IgG1, IgG2, IgG3 and IgG4.
Mammalian immunoglobins contain either lambda or kappa light chains.

Spécificité

Specificity is determined by mouse monoclonal isotyping strips. The purified immunoglobulin preparation is non-reactive with mouse IgA, IgM, IgG2a, IgG2b, or IgG3.

Application

IgG1, Kappa from murine myeloma has been used in:
  • chromatin immunoprecipitation (ChIP)
  • immunofluorescence
  • immunocapture
  • enzyme immunoassay
  • immunohistochemistry

Actions biochimiques/physiologiques

IgG1 is the most abundant and its deficiency results in hypogammaglobulinemia. IgG antibody have enormous therapeutic potential and the Fc region is involved the development of therapeutic antibody.

Forme physique

Solution in 0.02 M Tris buffered saline, pH 8.0, containing 0.02% sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

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Margarida Varela Dos Santos et al.
Gynecologic oncology, 176, 76-81 (2023-07-22)
To analyze the expression and prognostic role of L1CAM in tubo-ovarian high-grade serous carcinoma (HGSC). L1CAM protein expression by immunohistochemistry was analyzed in 644 HGSC (413 effusions, 231 surgical specimens). Expression was analyzed for association with clinicopathologic parameters and survival.
Elisabeth Smogeli et al.
BMC cancer, 16, 596-596 (2016-08-05)
L1 cell adhesion molecule (L1CAM) overexpression has been reported to be strongly associated with poor prognosis in early stage endometrial cancer (EC). We aimed at the validation of L1CAM as a marker of poor prognosis in an independent study population.
Jing Wen et al.
Journal of vascular surgery, 46(5), 1014-1025 (2007-10-02)
The syndecan family of cell surface proteoglycans can bind and modulate the activity of a diverse group of soluble and insoluble ligands, which have been shown to modulate events relevant to acute tissue repair and chronic injury responses. The expression
Margarida Varela Dos Santos et al.
Clinical & experimental metastasis, 41(1), 69-76 (2023-12-23)
The objective of this study was to analyze the expression and prognostic role of the tight junction protein occludin in high-grade serous carcinoma (HGSC). Occludin protein expression by immunohistochemistry was analyzed in 602 HGSC (417 effusions, 185 surgical specimens). Expression
Conformational flexibility in the immunoglobulin-like domain of the hepatitis C virus glycoprotein E2
Vasiliauskaite I, et al.
mBio, 8(3), e00382-e00317 (2017)
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