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M4699

Sigma-Aldrich

MTEP hydrochloride

≥98% (HPLC)

Synonyme(s) :

MTEP hydrochloride, 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine hydrochloride

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About This Item

Formule empirique (notation de Hill):
C11H8N2SHCl
Numéro CAS:
1186195-60-7
Poids moléculaire :
236.72
Numéro MDL:
MFCD08458895
Code UNSPSC :
12352200
ID de substance PubChem :
329817993
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Conditions de stockage

desiccated

Couleur

white to beige

Solubilité

H2O: 30 mg/mL, clear

Auteur

Merck & Co., Inc., Kenilworth, NJ, U.S.

Température de stockage

2-8°C

Chaîne SMILES 

Cl.Cc1nc(cs1)C#Cc2cccnc2

InChI

1S/C11H8N2S.ClH/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10;/h2-3,6-8H,1H3;1H

Clé InChI

YCIOJDKGCWAHLR-UHFFFAOYSA-N

Actions biochimiques/physiologiques

MTEP is a potent and highly selective antagonist for mGluR5.

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Richard M Cleva et al.
Frontiers in pharmacology, 2, 93-93 (2012-01-11)
Pharmacological manipulation of the type 5 metabotropic glutamate (mGlu5) receptor alters various addiction related behaviors such as drug self-administration and the extinction and reinstatement of drug-seeking behavior. However, the effects of pharmacological modulation of mGlu5 receptors on brain reward function
Tomas Ondrejcak et al.
Neurobiology of disease, 127, 582-590 (2019-03-27)
Soluble synaptotoxic aggregates of the main pathological proteins of Alzheimer's disease, amyloid β-protein (Aß) and tau, have rapid and potent inhibitory effects on long-term potentiation (LTP). Although the promotion of synaptic weakening mechanisms, including long-term depression (LTD), is posited to
Jongyun Myeong et al.
Cell reports, 41(11), 111820-111820 (2022-12-15)
Synaptic facilitation is a major form of short-term plasticity typically driven by an increase in residual presynaptic calcium. Using near-total internal reflection fluorescence (near-TIRF) imaging of single vesicle release in cultured hippocampal synapses, we demonstrate a distinctive, release-dependent form of
M Frankowska et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 71(4) (2020-12-15)
The abundance of research indicates that enriched environment acts as a beneficial factor reducing the risks of relapse in substance use disorder. There is also strong evidence showing the engagement of brain dopaminergic and glutamatergic signaling through the dopamine D2-like
Rianne R Campbell et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(14), 2745-2761 (2019-02-10)
The bed nucleus of the stria terminalis (BNST) is part of the limbic-hypothalamic system important for behavioral responses to stress, and glutamate transmission within this region has been implicated in the neurobiology of alcoholism. Herein, we used a combination of
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