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M4074

Sigma-Aldrich

Mometasone furoate

≥98% (HPLC)

Synonyme(s) :

(11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione

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About This Item

Formule empirique (notation de Hill) :
C27H30Cl2O6
Numéro CAS:
83919-23-7
Poids moléculaire :
521.43
Numéro MDL:
MFCD00866003
Code UNSPSC :
51111800
ID de substance PubChem :
329817988
Nomenclature NACRES :
NA.77

Essai

≥98% (HPLC)

Forme

powder

Activité optique

[α]/D +50 to +60°, c = 0.5 in methanol

Couleur

white to off-white

Solubilité

DMSO: ≥20 mg/mL

Auteur

Schering Plough

Température de stockage

2-8°C

Chaîne SMILES 

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c5ccco5)C(=O)CCl

InChI

1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1

Clé InChI

WOFMFGQZHJDGCX-ZULDAHANSA-N

Informations sur le gène

human ... NR3C1(2908)

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Application

Mometasone furoate has been used to study its effect on Leishmania major amastigotes.

Actions biochimiques/physiologiques

Mometasone furoate is a 17-heterocyclic intranasal corticosteroid. It is effectively used as a first-line daily intranasal therapeutic for allergic rhinitis and nasal polyposis. Mometasone furoate is also used as an adjunct to anti-bacterials for treating acute rhinosinusitis. In addition, it relieves the symptoms of asthma in both adults and adolescents by exhibiting a broad spectrum of anti-inflammatory properties.
Mometasone furoate is an anti-inflammatory glucocorticoid.

Caractéristiques et avantages

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H360D

Classification des risques

Repr. 1B

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
0000402485
0000402485
0000180751
0000180750
0000180751

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Consulter la Bibliothèque de documents

An In Vitro Investigation of the Effects of the Glucocorticoid on Leishmania major Amastigotes
Renani EH, et al.
Avicenna journal of phytomedicine, 6(4), 127-132 (2019)
Inhaled Mometasone Furoate
Sharpe M and Jarvis B
Drugs, 61(9), 1325-1350 (2001)
S-H Wu et al.
The British journal of dermatology, 168(1), 172-178 (2012-07-28)
Lipoxins are potential anti-inflammatory mediators and serve as an endogenous 'braking signal' in the inflammatory process. Accumulating evidence has indicated the efficacy of lipoxin A(4) (LXA(4) ) and its analogs in the treatment of many animal models of inflammatory diseases.
Johanna Svensson et al.
Primary care respiratory journal : journal of the General Practice Airways Group, 21(4), 412-418 (2012-09-25)
Acute rhinosinusitis is a common disease with an increasing incidence rate. It causes substantial costs to the individual and to society through healthcare consumption and absence from work. The use of antibiotics is widespread in the treatment of acute rhinosinusitis
David W Kennedy
Expert review of respiratory medicine, 6(5), 493-498 (2012-11-09)
Chronic rhinosinusitis is widely recognized as one of the most common chronic disease entities. Since its introduction in the USA in 1985, the role of functional endoscopic sinus surgery as an adjunct to medical therapy in the treatment of chronic
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