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M3655

Sigma-Aldrich

D-Mannose 6-phosphate sodium salt

≥98% (HPLC)

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About This Item

Formule linéaire :
C6H12O9PNa
Numéro CAS:
70442-25-0
Poids moléculaire :
282.12
Numéro MDL:
MFCD00135859
Code UNSPSC :
12352201
ID de substance PubChem :
24896863
Nomenclature NACRES :
NA.25

Source biologique

synthetic (inorganic)

Pureté

≥98% (HPLC)

Forme

powder

Technique(s)

HPLC: suitable

Impuretés

<12% water (Karl Fischer)

Couleur

white

Solubilité

water: 50 mg/mL, clear to cloudy, colorless

Traces de cations

Na: 7.3-9.0% (anhydrous)

Température de stockage

2-8°C

Chaîne SMILES 

[Na].OC(COP(O)(O)=O)C(O)C(O)C(O)C=O

InChI

1S/C6H13O9P.Na.H/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14;;/h1,3-6,8-11H,2H2,(H2,12,13,14);;

Clé InChI

RUFPTDNHMAGVMV-UHFFFAOYSA-N

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Description générale

Mannose is a monosaccharide.

Application

Mannose has been used in a study to assess in vivo targeting of alveolar macrophages. It has also been used in a study to investigate genetic engineering of the phosphocarrier protein NPr.

Actions biochimiques/physiologiques

Mannose-6-Pis a molecule bound by lectin in the immune system. It is converted to fructose 6-phosphate by mannose phosphate isomerase and is a key targeting signal for acid hydrolase precursor proteins that are transported to lysosomes.

Autres remarques

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Yossef Lopez-de Los Santos et al.
The Journal of biological chemistry, 287(35), 29931-29939 (2012-07-07)
The Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system (PTS) in prokaryotes mediates the uptake and phosphorylation of its numerous substrates through a phosphoryl transfer chain where a phosphoryl transfer protein, HPr, transfers its phosphoryl group to any of several sugar-specific Enzyme IIA
Maria Francisca Coutinho et al.
Molecular genetics and metabolism, 105(4), 542-550 (2012-01-24)
Lysosomal hydrolases are synthesized in the rough endoplasmic reticulum and specifically transported through the Golgi apparatus to the trans-Golgi network, from which transport vesicles bud to deliver them to the endosomal/lysosomal compartment. The explanation of how are the lysosomal enzymes
Ningning Yang et al.
Journal of controlled release : official journal of the Controlled Release Society, 155(2), 326-330 (2011-07-19)
Triplex-forming oligonucleotides (TFOs) represent an antigene approach for gene regulation through direct interaction with genomic DNA. While this strategy holds great promise owing to the fact that only two alleles need silencing to impact gene regulation, delivering TFOs to target
Katrin Marschner et al.
Science (New York, N.Y.), 333(6038), 87-90 (2011-07-02)
Mucolipidosis II is a severe lysosomal storage disorder caused by defects in the α and β subunits of the hexameric N-acetylglucosamine-1-phosphotransferase complex essential for the formation of the mannose 6-phosphate targeting signal on lysosomal enzymes. Cleavage of the membrane-bound α/β-subunit
Wei Cheong Ngeow et al.
Journal of anatomy, 219(5), 638-645 (2011-08-05)
Microsurgical repair of transected peripheral nerves is compromised by the formation of scar tissue and the development of a neuroma, thereby limiting the success of regeneration. The aim of this study was to quantify histomorphometrically the structural changes in neural
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