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M265

Sigma-Aldrich

Anti-Glutamate Receptor NMDAR2B (NR2B) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonyme(s) :

Anti-DEE27, Anti-EIEE27, Anti-GluN2B, Anti-MRD6, Anti-NMDAR2B, Anti-NR2B, Anti-NR3, Anti-hNR3

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About This Item

Numéro MDL:
MFCD01865097
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Poids mol.

antigen 180 kDa

Espèces réactives

rat, human, mouse

Technique(s)

immunohistochemistry (frozen sections): 1:1,000
immunoprecipitation (IP): 3 μL using 200 μg of rat brain
western blot: 1 μg/mL using 35S-Protein A (with ECL dilutions may be higher)

Numéro d'accès UniProt

Q13224

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... GRIN2B(2904)
mouse ... Grin2b(14812)
rat ... Grin2b(24410)

Description générale

Glutamate ionotropic receptor N-methyl-D-aspartate (NMDA) type subunit 2B (GRIN2B) codes for N-methyl D-aspartate receptor subtype 2B (GluN2B). It is an important constituent of the N-methyl D-aspartate receptor protein. GRIN2B gene is located on human chromosome 12p13.1.

Immunogène

C-terminal portion of NR2B (amino acids 984-1104).

Application

Anti-Glutamate Receptor NMDAR2B (NR2B) antibody is suitable for use in immunohistochemistry (1:1,000 dilution, using frozen sections), immunoprecipitation (3 μL using 200 μg of rat brain), and indirect ELISA. The antibody may also be used for western blot (1 μg/mL using (35S)-Protein A) and immunoblot (180 kDa).
Anti-Glutamate Receptor NMDAR2B (NR2B) antibody produced in rabbit has been used in western blotting.

Actions biochimiques/physiologiques

Glutamate ionotropic receptor N-methyl-D-aspartate (NMDA) type subunit 2B (GRIN2B) plays a key role in synaptic plasticity, language acquisition, neural pattern formation and short-term memory. Mutations on GRIN2B gene results in Parkinson′s disease, schizophrenia, bipolar disorder, Alzheimer′s disease and obsessive-compulsive disorder.
The functional N-Methyl-D-Aspartate (NMDA) receptor complex consists of a NMDAR1 (NR1) subunit and atleast one NMDAR2 subunit ranging from NR2A-NR2D. These receptor complexes have been implicated in cochlear functions and neuronal plasticity. The C-terminal end of NR2B receptor may regulate synaptic localization.

Forme physique

Lyophilized from ammonium bicarbonate (5 mM).

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Description
Tarif

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Steve Standley et al.
PloS one, 7(6), e39585-e39585 (2012-07-05)
NMDA receptor NR2A/B subunits have PDZ-binding domains on their extreme C-termini that are known to interact with the PSD-95 family and other PDZ proteins. We explore the interactions between PSD-95 family proteins and the NR2A/B cytoplasmic tails, and the consequences
Mi Zhou et al.
Neuroscience, 376, 24-39 (2018-02-17)
The amygdala plays a key role in the pathophysiology of depression, but the molecular mechanisms underlying amygdalar hyperactivity in depression remain unclear. In this study, we used a chronic mild stress (CMS) protocol to separate susceptible and insusceptible rat subgroups.
Maowen Ba et al.
Behavioural brain research, 356, 41-45 (2018-08-22)
Augmented function of N-methyl-d-aspartate receptor subunit 2B (NR2B) and Src protein tyrosine kinase have been demonstrated to get involved in the pathological mechanisms of dyskinesia. In view of functional interactions between NR2B and Src, we investigated the effects of uncoupling
D Joelson et al.
Microscopy research and technique, 41(3), 246-262 (1998-05-30)
The distribution of immunoreactivity for the ionotropic N-methyl-D-aspartate (NMDA) receptor subunits was mapped in the cochlear nucleus of postnatal day (P) 7, P14, P21, and P28 gerbils. Frozen sections and serial plastic sections of tissue were incubated with antibodies to
R S Petralia et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 14(10), 6102-6120 (1994-10-01)
Neuronal plasticity associated with learning, memory and development is controlled, in part, by NMDA receptors, which are complexes consisting of the subunit NMDAR1 (NR1) and one or more NMDAR2 subunits (NR2A-NR2D). We made a polyclonal antibody to a C-terminus peptide
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