L9908

LY-294,002 hydrochloride

from microbial (Staphylococcus roseus), ≥98% (HPLC), solid, PI3K inhibitor

• Synonyme(s) : 2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride
• Formule empirique (notation de Hill): C₁₉H₁₇NO₃ · HCl
• Numéro CAS: 934389-88-5
• Poids moléculaire : 343.80
• Numéro MDL: MFCD00270881
• Code UNSPSC : 12352207
• ID de substance PubChem : 24278828
• Nomenclature NACRES : NA.77

Propriétés

• product name: LY-294,002 hydrochloride, solid, ≥98% (HPLC)
• Source biologique: microbial (Staphylococcus roseus)
• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Couleur: white to off-white
• Solubilité: DMSO: >5 mg/mL; H₂O: insoluble
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4
• InChI: 1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
• Clé InChI: CZQHHVNHHHRRDU-UHFFFAOYSA-N

Description

Description générale

LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.

Application

LY-294,002 hydrochloride has been used in the inhibition of:

• phosphoinositide 3-kinase (PI3K) in human lung cancer cell line
• autophagy in mesenchymal stem cells (MSCs).
• serine/threonine-specific protein kinase (AKT) signaling in fibroblasts and cardiac cells.

Actions biochimiques/physiologiques

Specific cell permeable phosphatidylinositol 3-kinase inhibitor.

Caractéristiques et avantages

This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)